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Researcher (parental leave position)Therapeutic Protein Engineering at the DDD platform Full-time
Researcher (Parental Leave Position) Therapeutic Protein Engineering at the DDD Platform
The Drug Discovery & Development platform at the Science for Life Laboratory (SciLifeLab DDD) is a national infrastructure for academic drug development with the task of translating academic discoveries into drug candidates for further commercial development. The business, which has existed for almost ten years, has, among other things, contributed to >10 new companies and four clinical drug candidates. The platform includes around 40 employees at six Swedish universities who all support collaborative projects with external academic project owners.
The DDD unit “Therapeutic Protein Engineering” (TPE) is attached to KTH and located at SciLifeLab DDD, Solna. The unit's main responsibility is to deliver well-characterized antibodies, antigens, and target proteins to the projects, as well as be technically responsible for the selection-based projects.
Your tasks will be to develop expression and purification protocols for challenging target proteins in our drug discovery projects, as well as to analyze and characterize protein properties such as functionality and conformation using various biochemical and biophysical techniques. Your role will be both lab-based and coordinative. You are innovative, creative and a problem solver.
Qualifications
Requirements
- A doctoral degree or an equivalent foreign degree in biotechnology, biochemistry or molecular biology
- Thorough experience in cloning, overexpression and purification of proteins in bacteria, insect cells and/or mammalian cells
- Protein purification using ÄKTA or comparable systems
- Experience with protein engineering
- Thorough knowledge of standard protein analysis methods
Preferred qualifications
- Experience from biotech/pharmaceutical industry or relevant academic research environment
- Experience with structural biology, especially cryo-EM
- Experience with biophysical protein analysis methods, e.g. SPR, BLI, ITC, DLS and DSF
- Experience with protein engineering
- Experience with display methods for selection of affinity molecules, e.g. antibody fragments
- Excellent writing and communication skills
- Project management and coordination
- Knowledge of diversity and equal opportunity issues, with specific focus on gender equality
Great emphasis will be placed on personal skills.
Join us at KTH
KTH shapes the future through education, research and innovation. As a leading international technical university, we play an active role in advancing the transition towards a sustainable society. At KTH, you have the opportunity to grow and develop in a creative and dynamic environment, with good working conditions and attractive benefits. Equality, diversity and equal opportunities are essential to quality and form an integral part of KTH's core values as a university and public authority.
Learn more about our benefits and what it's like to work and grow at KTH.
To apply for the position
Log into KTH's recruitment system in order to apply for this position. You are responsible to ensure that your application is complete according to the instructions in the ad.
The application must contain:
- CV including relevant professional experience and knowledge.
- Copy of diplomas and grades from your previous university studies. Translations into English or Swedish if the original documents are not issued in either of these languages.
- Personal letter (1 page)
Your complete application must be received by KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time).
About the employment
The employment is valid for a limited time according to the agreement – for up to 11 months, with access according to agreement.
Other information
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