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Postdoctoral Fellow
Cancer Epigenetics and Metabolism Full-time
Postdoctoral position is open for highly motivated candidates in the laboratory of Dr. Subhamoy Dasgupta, Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, NY- a National Cancer Institute (NCI) designated comprehensive cancer center. Some of the ongoing research directions in Dasgupta lab are:
(a) Discovering tumor metabolic adaptations that promote metastatic progression.
(b) Understanding the mechanisms regulating organ specific adaptation of tumors leading to metastatic colonization. Strong focus on bone-metastatic tumors.
(c) Deciphering epigenetic landscape of aggressive tumors and identifying how nutrient signaling and metabolism modulates histone acetylation/methylation impacting chromatin accessibility.
(d) Nuclear receptor and coactivator dependent transcriptional regulation of hormone-dependent tumors and defining the mechanisms driving therapeutic resistance.
(e) Interrogate the tumor-immune microenvironment and discover the mechanisms driving tumor-immune escape.
State of art facilities such as proteomics, genomics (scRNAseq, RNAseq, ATACseq, ChIPseq, etc.), and metabolomics (steady state, isotope tracing, tumor interstitial fluid, etc.) along with molecular biology and immunological techniques are widely used in the laboratory. Multiple models systems, including Genetically Engineered Mouse Models (GEMMs), patient-derived xenograft (PDX), and syngeneic tumor models are used to address challenging mechanisms in cancer progression and metastasis. Currently the laboratory is funded by multiple grants from National Cancer Institute (NCI), NIH Director’s Award, Department of Defense (DoD), and other private foundations. Recent publications from the lab:
a) Dasgupta S, et al, Journal of Clinical Investigation, 2015, PMID: 25664849;
b) Dasgupta S, et al, Nature, 556, 249–254, 2018, PMID: 29615789;
c) Sawant Dessai A, et al, Cancer Research, 2020, PMID: 33115805;
d) Dai T., et al, Cell Reports, 2022, PMID: 36476868;
e) Wu YH, et al, Molecular Cancer Therapeutics, 2022, PMID: 35666809.
f) Singh, et al, PNAS, 2023, PMID: 37155905
g) Sawant Dessai A, et al, Nature Communications (Under Review)
The search is primarily targeted towards scientists who are completing their PhD or have recently graduated with first author publications demonstrating their skills in gene transcription, epigenetics, and cancer biology. Experience of working with mouse models will be preferred. The candidate should possess outstanding written and verbal communication skills. Candidates from all backgrounds are encouraged to apply.
Roswell Park Comprehensive Cancer Center, one of the world’s oldest cancer centers established in 1898, is known for numerous seminal basic science and translational discoveries in oncology. Roswell Park has state-of-the-art research infrastructure enabling all aspects of modern biomedical research – from discovery work towards clinical validation – and provides a highly stimulating academic and clinical environment.
Location: Buffalo, New York, USA
Salary: Competitive with healthcare benefits
Discipline: Cancer Biology, Epigenetics, Molecular Biology, Signal Transduction, Cell Biology