Scientist Full-time

Scientist (Oligo Synthesis) – Sbx Molecular Engineering

At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.

Roche Diagnostics acquired Stratos Genomics in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX™). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.

The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful.

***Please include a cover letter outlining why you want to work with us, your specific interest in SBX technology (technical) and how you would contribute, this is important.***

The Opportunity:

• Research, design and execute innovative and well-controlled experiments, with high attention to detail.
• Identify and troubleshoot problems in creative ways.
• Contribute to the definition and timely achievement of project goals.
• Follow SOPs to aid in the production of reagents and starting materials.
• Participate in the production of reagents and starting materials.
• Perform data analysis and protocol development.
• Maintain accurate, detailed, and reliable laboratory records.
• Present findings at group or departmental meetings.
• Maintain the lab's cleanliness and organization.
• Develop and propose improved processes to fulfill the above functions.

Who you are:

• You have a minimum of 2 years laboratory experience in advanced oligo synthesis (e.g. use and development of non-standard phosphoramidites and reagents, branched or cyclic structures, and instrument modification).
• You hold a Bachelor's degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or related field; or equivalent combination of education and work experience, MS or PHD Preferred. 5+ years of experience, less with advanced degrees.
• Ideally, you will have:
• Demonstrated ability to understand and develop novel chemistry for automated oligo synthesis:
• Coupling of Phosphoramidites
• Oxidation
• Detritylation
• Capping
• Able to manipulate and engineer novel solutions with complex automated fluidics (i.e. Automated Oligo Synthesizers)
• Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification, and storage.
• Technical background in next-generation DNA sequencing
• Experience with HPLC, MS, NMR, inert atmosphere chambers, and manual pipetting.

Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of Seattle, WA is 81,100.00 – 150,700.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed here.