Scientist–ADC Biology (non PhD) Full-time

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that change patients' lives. Your work will have a profound impact on improving patients' lives globally. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will leverage cutting-edge design and process development capabilities to accelerate and deliver best-in-class medicines to patients worldwide.

Role Summary

As a Scientist (non-PhD) on our ADC Biology team, you will be a key driver in advancing the next-generation ADC technologies through collaborative, cross-functional research that spans early discovery to pre-clinical development. You will develop assays and execute screening and identification of novel chemotypes that function as payloads for antibody drug conjugates for cancer therapy. You will work collaboratively with chemistry and other cross functional teams to understand mechanism of action of identified payloads. You will analyze, interpret and communicate the data effectively to key stakeholders.

Key Responsibilities

• Apply cellular, biochemical, immunological, and molecular biology laboratory techniques to preclinical research projects in the areas of Cancer signaling and Cancer biology
• Investigate MOAs of our therapeutics through development, optimization, and execution of complex assays
• Interact and collaborate with other functional groups across research
• Provide leadership within technical area of expertise; may train, direct or mentor others
• Design and execute key experiments to investigate novel therapeutic targets and MOAs of novel payloads to enable clear go/no-go decisions.
• Independently analyze data, document results, and present findings to large and small audiences
• Maintain rigorous records of experimental progress using electronic laboratory notebooks
• Present experimental results and scientific rationale to colleagues
• Execute molecular, biochemical and cell-based methodologies including cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling multicolor flow cytometry, immunofluorescent and live cell microscopy.
• Aid in execution and analysis of additional experiments as need arises within the ADC discovery research team

Minimum Requirements

• Bachelor's degree in Cellular or Molecular Biology, Immunology, Biochemistry or related field and 6+ years' relevant industry ADC Biology or small molecule experience OR
• M.S. degree in Cellular or Molecular Biology, Immunology, Biochemistry or related field with 4+ years' relevant industry ADC Biology or small molecule experience
• Experience with Microsoft Office (Excel, Word, PowerPoint) and analytical software programs (e.g., Prism, FlowJo)
• Experience designing, performing and interpreting complex experiments that require significant insight into problems being addressed with some guidance
• Working knowledge of the Cancer Biology and Cancer therapeutics areas, especially small molecule agents, Biologics and ADCs
• Experience working independently and working on multiple projects
• Experience collaborating across teams and a variety of disciplines to provide experimental expertise and support others on joint projects
• Experience leading parts of projects or initiatives within area of expertise
• Excellent written/oral communication skills with experience presenting/sharing details of the work with key stakeholders

Preferred Requirements

• Experience in experimental cancer biology, biochemical and/or immunological techniques (e.g., Cell culture, cytotoxicity assays, HiBit, HTRF, ELISA, western blotting, automated liquid handling multicolor flow cytometry, immunofluorescent and live cell microscopy).
• Background knowledge in the field of cell signaling and biochemistry
• Experience developing complex cell and biochemical assays

Physical/Mental Requirements

• Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
• Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes/glasses)

Non-Standard Work Schedule, Travel or Environment Requirements

• Majority of work will be performed during the standard workday, but ability to work flexible hours when needed is preferable

Work Location Assignment: On Premise