Scientist – AI & ML for Protein and Antibody Engineering Full-time

Join Roche's Computational Sciences Center of Excellence

At Roche, you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Opportunity

We are seeking a highly skilled Scientist with strong expertise in AI and Machine Learning applied to protein and antibody structure, function, and engineering. The successful candidate will work at the intersection of computational modeling, modern AI technologies, and biologics drug discovery, applying and implementing state-of-the-art ML approaches to design and optimize therapeutic proteins and antibodies.

As a Scientist in the Computational Sciences Center of Excellence, you will leverage generative AI to accelerate antibody discovery, working within a unified team spanning Genentech and Roche Pharma. This role offers a unique opportunity to bridge computational and experimental sciences and deliver transformative medicines to patients.

• Apply novel Machine Learning and Computational Biology methods to address complex research questions in Large Molecule Drug Discovery (LMDD), with a focus on protein and antibodies
• Develop, implement, and deploy discriminative and generative models (e.g., diffusion models, LLMs) to predict structure, affinity, function of proteins
• Collaborate closely with cross-functional teams to integrate and clean biological data from heterogeneous sources.
• Design and engineer new de novo proteins and antibodies using state-of-the-art computational approaches for drug development purposes.
• Collaborate closely with cross-functional teams to integrate, curate, and analyze biological data from heterogeneous sources.
• Facilitate collaboration between experimental scientists and computational experts to maximize the impact of data and model sharing.
• Contribute to scientific innovation through publications, internal reports, and presentations at internal and external scientific venues.

Who You Are

• PhD in Computational Biology, Protein Engineering, Machine Learning, Computer Science, or a related discipline.
• Expert-level understanding of protein and antibody structure–function relationships, enabling rational design and engineering decisions grounded in structural, biophysical, and functional principles.
• Strong hands-on experience in machine learning and deep learning, with the ability to independently develop, train, and evaluate models.
• Proven ability to work at both application and implementation levels, including adapting state-of-the-art models to drug discovery problems and modifying architectures or training strategies as needed.
• Advanced programming expertise in Python and deep learning frameworks such as PyTorch, TensorFlow, or JAX, applied to protein/antibody design.
• Strong scientific track record, including first-author publications in high-impact journals or conferences.
• Excellent communication skills and a collaborative mindset, with the ability to bridge computational and experimental disciplines.
• Experience with molecular dynamics simulations is a plus.

Ready to take the next step? We'd love to hear from you. Apply now to explore this exciting opportunity!

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an Equal Opportunity Employer.