Scientist – BioAnalytical Research Full-time

Job Title: Scientist Skilled In Protein Mass Spectrometry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

The Bioanalytical Research Group (BAR) at Lilly's research facility in South San Francisco, CA is seeking a strong scientist skilled in protein mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and antibody-drug-conjugates (ADCs). The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimized ADC candidates to advance to clinical testing.

Primary Responsibilities:

• The development and application of QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and bio-distribution of ADC drug candidates in pre-clinical animal models.
• The application of mass spectrometry and wet biochemistry to answer questions related to target engagement and ADC mechanism of action.
• This on-site role supports sample preparation, experimental develop and mass-spec analysis of biological samples as well as data analysis/interpretation from in-vivo studies from triple-quad and orbitrap mass spectrometers.
• Characterization of recombinant proteins, antibodies, and ADCs using intact-MS and peptide mapping for routine QC using high-resolution mass spec platforms (Oribtrap).

Job Requirements:

• B.S. with 5+ years in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or scientific field
• Experience with mass spectrometry-based methods to support the bio-analysis of therapeutic proteins.
• Experience with a wide variety of sample preparation techniques including SPE, LLE, PPT, or immunoaffinity/hybridization techniques.

Additional Experience is Preferred:

• Masters Degree in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or scientific subject area and 3+ years of significant work experience
• Knowledge of the operation and the routine maintenance of Thermo Orbitrap and Sciex QQQ mass spectrometers is preferred
• Excellent written and effective verbal communication.
• Strong work planning, record keeping and data analysis skills.
• Experience supporting ADC drug development, including assessing PK, Efficacy, and toxicology profiles in preclinical models and showcasing data to project teams is ideal.
• Knowledge of the ADME principles of biotherapeutic drugs.
• Experience with proteomics methods, DDA, nano-LC, DIA, or similar workflows in a drug discovery setting.

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Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 – $193,600.