Scientist – Discovery Biology, Oncology Full-time NEW

Scientist – Discovery Biology, Oncology

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

We are seeking an experienced individual with cancer research and oncology drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, creative scientist, with the ability to work across functions to advance small molecule programs from target discovery and validation to lead optimization, selection of drug candidate and IND-enabling biology related activities.

This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing various cellular assays to enable compound triaging and identification of potential drug candidate. In addition, the individual will work closely with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others.

In the role as a Scientist within Oncology Discovery Biology, the ideal candidate:

• Applies extensive scientific knowledge and technical skills to conduct molecular and cellular biology related studies to better understand target and disease biology
• Uses current and new technologies for function-based characterization for small molecule hit validation, mechanism of action understanding, and compound triaging/ranking
• Designs and executes molecular and cellular experiments independently, troubleshoots as needed, interprets and discusses data, with accurate, timely and detailed record-keeping
• Designing, optimizing, and executing molecular and cellular assays for cytotoxic payload screening, characterization, and mechanism of action studies
• Applying understanding of cancer biology to hypothesize and validate novel cytotoxic payloads and combination strategies
• Generating and characterizing relevant cancer cell models, including engineering drug-resistant lines and utilizing genetic tools (CRISPR, shRNA, siRNA, lentiviral overexpression).
• Conducting studies to evaluate small molecule or payload efficacy, selectivity, and synergy in 2D/3D/spheroid systems, and developing assays for cytotoxicity, proliferation, apoptosis, and high-content imaging.
• Collaborating closely with ADC biology, chemistry, pharmacology, and predictive science teams to enable seamless integration of payload screening data into program decision-making.
• Generates and characterizes relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA, lentiviral mediated target overexpression, etc.) and establishing drug-resistant cell lines
• Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science, etc.
• Communicates via email, meetings, and reports utilizing excellent communication and interpersonal skills
• Makes presentations in small, multidisciplinary meetings, logically presenting data and interpretation to convey clear, key messages

Experience:

Basic Qualifications:

• Bachelor's Degree with 5+ years of academic and / or industry experience, industry experience is desired
• Or
• Master's Degree with 3+ years of academic and / or industry experience, industry experience is desired
• Or
• Ph.D. or equivalent advanced degree in the Life Sciences with no experience necessary

Preferred Qualifications:

• Extensive knowledge and track record in cancer research and industry experience in oncology drug discovery, or Ph.D. with a strong publication record in top-tier peer reviewed journals
• Proficiency in molecular and cellular biology techniques relevant to small molecule drug discovery, including high-content imaging, cytotoxicity/proliferation assays (CyQuant, CTG, apoptosis, IncuCyte), flow cytometry, and cell line engineering.
• Antibody Drug Conjugate and DNA damage repair biology experience considered a plus
• Familiarity with novel assay development and orthogonal pathway combination studies to evaluate synergistic effects with cytotoxic payloads.
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner
• Attention to detail with excellent organizational and record keeping skills is a requirement
• Excellent oral and written communication skills. Ability to communicate well with peers and supervisors.
• Strong problem-solving skills and understanding of relevant scientific principles

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodations/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/