Scientist, Early CVRM Full-time

Scientist, Early CVRM

We are seeking a highly motivated Scientist to join the Metabolism Bioscience team in the Early Cardiovascular, Renal, and Metabolism (CVRM) therapeutic area based in Gaithersburg, MD. You will contribute to advancing early-stage drug discovery programs by uncovering novel disease biology, validating new targets, and generating high quality experimental data that drives strategic decisions in the early pipeline.

Key Responsibilities

• Execute and interpret in vivo experiments focused on CVRM-relevant biological pathways.
• Develop, optimize, validate and implement in vivo and ex vivo models of metabolic and cardiovascular diseases to support our Early CVRM pipeline.
• Conduct data analysis and clearly communicate results to cross-functional project teams.
• Maintain accurate scientific documentation and ensure compliance with safety and quality guidelines.
• Stay current with scientific literature and industry advances in CVRM research.

Required Qualifications

• Bachelor's degree in Biology, Pharmacology, Physiology, or a related field with 2+ years of relevant experience, or a Master's degree in a related field with 0+ years of relevant experience.
• Hands-on experience with animal models, including:
• Technical expertise with handling mice and rats, including dosing via intraperitoneal (IP), intravenous (IV), subcutaneous (SC), and oral gavage routes of administration.
• Cage handling experience, including cage change, monitoring body weight and food intake.
• Expertise in blood collection methods in mice and rats, including sub-mandibular, tail-bleeds, cardiac puncture and vena cava as well as terminal tissue collections including heart, muscle, adipose, and liver.
• Strong data analysis and scientific communication skills.
• Demonstrated ability to work independently as well as collaboratively in a team setting in a fast paced R&D environment.

Preferred Qualifications

• Industry or academic research experience in early-stage drug discovery.
• Proficiency in molecular and cellular biology techniques (e.g., qPCR, Western blot, ELISAs etc.).
• Rodent surgical expertise, including subcutaneous implantation of Alzet pumps, liver biopsies, thoracic aortic constriction (TAC), etc.
• Experience working with rodent models of metabolic and cardiovascular diseases – including diet-induced obese (DIO) mice and rats, ZSF-1 rats, genetic cardiomyopathy models, AngII infusion, etc.

Key Competencies

• Strong scientific curiosity and problem-solving ability
• Rigor and attention to detail
• Clear communication and teamwork
• Ability to prioritize and manage multiple experiments
• Adaptability and learning agility

AstraZeneca offers an inspiring environment where your expertise can make a profound impact. With a commitment to continuous improvement and innovation, we embrace challenges and thrive on collaboration. Our dynamic approach ensures that every setback is an opportunity for growth. Here, you'll be part of a team that values curiosity and courage, pushing boundaries to deliver life-changing medicines to patients worldwide.

At AstraZeneca, we seize opportunities to innovate and redefine what's possible in biopharmaceuticals. Our mission to deliver transformative medicines is underpinned by a culture of collaboration, inclusivity, and ambition. Join us in a role where your work directly gives to breakthroughs in oncology, empowering patients and changing lives.

Ready to take the next step in your career? Apply now and be part of something extraordinary!