Scientist, Early Stage Formulation Full-time NEW

Scientist, Early Stage Formulation Sciences

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

The Biopharmaceutical Development (BPD) group is a multi-disciplinary scientific function providing expertise in Process/Analytical/Formulation/Device Development and Characterization with integrated Bioprocess Engineering, Clinical Manufacturing, and Supply Chain and Logistics operations. The group is also responsible for transferring the processes to different clinical and commercial sites in and outside the AstraZeneca organization. BPD group is present in multiple sites in US and UK.

This position is in Early Stage Formulation Sciences within BPD, responsible for designing and developing formulation and Drug Product presentations from pre-clinical through Phase 3 clinical trials and in support of commercialization.

Main Duties & Responsibilities:

• Perform research in state-of-the-art laboratories that are focused on formulation and process development of biologics
• Evaluate protein formulation development, characterization, and stability testing
• Contribute to advancing AstraZeneca's pipeline of diverse antibody modalities
• Drive innovation across a variety of scientific domains
• Make in-depth experimental observations, analyze and interpret experimental results, and present scientific data
• Act as Functional representative on CMC teams
• Author CMC sections for regulatory filings

Education & Experience Requirements:

• M.S. in Chemical/biochemical engineering, Chemistry, Biochemistry, Pharmaceutical Sciences or related field with a minimum of 2 years of relevant industry experience.

Required Skills:

• Experience with formulation development, biophysical characterization, and stability testing of proteins
• Science oriented, highly motivated self-starter with drive to succeed
• Meticulous in execution of laboratory experiments and reporting
• Good communication skills, strong interpersonal skills, and ability to thrive in an interdisciplinary fast paced environment

Desired Skills:

• Knowledge of stability and rheological properties of high concentration biologics formulations
• Knowledge of antibody formulation liabilities, formulation interactions, and desired properties like binding, stability, and developability
• Familiarity with antibody structure, different antibody modalities including multi-specifics and antibody-conjugates, and degradation mechanisms
• Familiarity with different routes of administration (intravenous, subcutaneous), delivery devices, and combination products
• Knowledge of Design of Experiments and statistical principles
• Ability to work effectively as an individual contributor and as a team member within a matrix environment.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial – finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.