Scientist, Formulation Discovery Full-time

Scientist Position At Verve Therapeutics

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines.

The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia.

In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.

Responsibilities:

We are seeking a motivated Scientist to join our Formulation Discovery team. The successful candidate will have a background in the preparation and characterization of nanoparticle-based delivery systems for nucleic acid therapeutics. In addition, the candidate will have to work in a multidisciplinary fast-paced team environment.

• Design and preparation of lipid nanoparticles (LNPs) for early-stage evaluation of delivery of nucleic acid payloads in cell-based and preclinical animal models.
• Characterization of LNPs through HPLC, DLS, spectroscopic techniques such as UV-Vis and fluorescence, ribogreen assays, and pKA.
• After successful screening and identification of lead LNP formulations, the candidate will have the opportunity to further streamline and advance the formulation towards clinical development.
• Design, preparation, and characterization of lipid nanoparticles for screening efficient delivery of nucleic acid payloads in preclinical animal models.
• Prepare technical reports and presentations pertaining to formulation development
• Generate/write protocols, and SOPs.
• Cross-functional collaboration
• Other duties as assigned

Basic Requirements:

• B.S. degree in chemical engineering, bioengineering, chemistry, pharmaceutical sciences, or another related field
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Additional Skills/Preferences:

• Experience with nanomedicinal or nanoparticle formulations preferred.
• Strong problem-solving skills, and creative/innovative thinking in problem solving.
• Ability to work independently and collaboratively in very dynamic interdisciplinary team environments.
• Proven track record in working with partners/collaborators is desirable.
• Organized, diligent, and innovative self-starter who continuously seeks to improve existing laboratory methods and processes.
• Effective verbal and written communication skills; proficiency in literature search and relevant computer software skills are required.

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Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 – $187,000.