Scientist III/IV: Purification Assessment and Analytics, Biotherapeutics Full-time

Scientist III/IV, Biotherapeutics Purification Assessment And Analytics

Boehringer Ingelheim is currently seeking an innovative and ambitious Scientist III/IV, Biotherapeutics Purification Assessment and Analytics to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility. We are seeking a talented and experienced Scientist III/IV who will conduct protein purification and analytics to support development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for designing and executing protein purification and analytics as well as, analyzing and interpreting assays and production data to understand inherent protein attributes and physicochemical stability. The ideal candidate will be an analytical thinker with creative problem-solving skills; a quick learner who takes the initiative and manages workflows for several projects with enthusiasm and resourcefulness; an effective collaborator, working with different functional areas to enhance project knowledge.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

***Candidate will be hired at level commensurate with experience and education***

Duties & Responsibilities

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Troubleshoot complex systems as necessary through process development. • Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS) • Evaluate new technologies and process changes to improve the productivity, quality and consistency of standard platform processes. • Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions, interpret and present findings to other Biotherapeutics Discovery colleagues. • Develop novel analytical methodologies and evaluate new technologies to improve purification team capabilities • Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function. • Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks as assigned by manager in a timely manner. • Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency. • Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP's and policies.

Requirements

Scientist III Requirements:

• Master's Degree from an accredited institution with three-plus (3+) years of experience in related scientific discipline, OR Bachelor's Degree from an accredited institution with seven-plus (7+) years of experience in related scientific discipline or equivalent experience in related field

Scientist IV Requirements:

• Master's degree plus six (6) years industry experience in related field or Bachelor's degree plus ten (10) years industry experience in related field or equivalent.

Requirements for both levels:

• Considerable experience with protein purification techniques such as affinity chromatography, ion exchange chromatography (AEX,CEX), Mixed mode chromatography (MMC), and/or Hydrophobic interaction chromatography (HIC)
• Experience conducting standard protein analytics to assess quality and stability (SDS-PAGE, CGE, U/HPLC, DLS)
• Knowledge and experience with protein expression preferred.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry principles underpinning protein interactions, stability, and biotherapeutic quality attributes.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.

Compensation Data

This position, Scientist III, Biotherapeutics, offers a base salary typically between $90,000.00 and $147,000.00 USD. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here.