Scientist, Oligo Platform Biology Full-time

High Throughput Oligo Screening Workflows

The successful candidate will help establish high throughput oligo screening workflows and capabilities within GSK's new oligo platform biology lab. They will be able to work with cross-functional teams across the organization on a variety of disease areas and oligo modalities. Oligo modalities being pursued include ASO, siRNA, SSO, and RNA editors.

Responsibilities Include

This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:

• Independently design, execute, and troubleshoot high throughput cell-based assays to support oligo platform and portfolio projects.
• Miniaturize (384-well) and adapt cell-based assays into automated workflows. Establish new screening workflows and draft SOPs in support of new programs.
• Analyze and present screening results, recommending courses of action based on datasets. Lead and participate in discussions with cross-functional teams to support lead discovery.
• Train other scientists in the team with new assays and automation.
• Be a key member of oligo biology team and serve as a strong representative on interdisciplinary project teams.

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

• MS with 3+ or BS with 5+ years' experience in molecular or cell biology or related field
• 2+ years of experience with high throughput assays and automated workflows
• Must be comfortable and have knowledge of liquid dispensers and liquid handlers (e.g. Viaflo96/384, Certus Flex, Tecan Fluent 1080).
• Experience in cell and molecular biology and techniques (e.g. mammalian cell culture, RNA/DNA isolation, transfection, PCR/qPCR, ELISA, Western Blot, gel electrophoresis, etc.)

Preferred Experience

If you have the following characteristics, it would be a plus:

• Experience in oligonucleotide therapeutics (e.g. ASO, siRNA, SSO, RNA Editors) is preferred.
• Experience with automating high throughput assays and liquid handler scripting is a plus.
• Experience with dPCR, NGS, and mammalian cell systems of liver, CNS, lung, and/or kidney origins are preferred.
• Independent individuals with strong initiative and ability to troubleshoot challenges and implement new solutions.
• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.