Scientist, Pharmacokinetics Full-time

Scientist Position in Transporter Science Group

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function of our company in West Point, Pennsylvania, is seeking a highly skilled and motivated Scientist to join the Transporter Science Group. The Transporter Science group is a center of excellence to design, execute, and integrate transporter related in vitro and preclinical studies to support our company's Portfolio through all stages of drug discovery and development. We are also driving cutting edge ADME-transporter science via development and implementation of novel in vitro and preclinical models, as well as translational approaches to enhance our capabilities to quantitatively predict the roles of transporters on ADME, drug-drug interactions (DDIs), efficacy, and toxicity of drugs in a diversified portfolio that spans various therapeutic areas and modalities.

In this position, candidates will be responsible to generate transporter related in vitro data to support discovery and development programs. Candidates will also have the opportunity to work closely with other scientists across the network to advance our scientific strategy via developing and implementing novel tools/emerging technologies. Successful candidates should have a passion for generating high quality data for use by project teams across a range of therapeutic areas and must be able to work independently with a range of in vitro assay systems. In addition, candidates will be conducting experiments using automated liquid handlers and other sophisticated scientific instrumentation. Candidates must have excellent written and verbal communications and experience working in a team environment.

Position Qualifications

Education Minimum Requirement:

A master's or bachelor's degree in a relevant field (e.g. Biochemistry, Biology, Biotechnology, Molecular and Cell Biology, Pharmacology; Pharmaceutical Sciences) with 1-3+ years of relevant laboratory experience

Required Experience and Skills:

• Demonstrated ability to design, perform and interpret in vitro studies generated in cell lines, hepatocytes or subcellular fractions per established protocols
• Cell culture, including aseptic techniques and maintenance of recombinant cell lines and primary cells
• Ability to work independently and effectively to develop and validate new assays with some technical and strategic supervision
• Proficiency in data handling software such as Excel and Graphpad, ability to document results accurately and generate reports to be shared with internal partners or regulatory agencies
• Strong communication and collaboration skills with flexibility to operate in a team environment
• Autonomy, attention to details, critical thinking, and growth mindset

Preferred Experience and Skills:

• Hands-on experience and knowledge of transporter-related in vitro studies (eg, cellular uptake studies, transporter inhibition assays)
• Basic understanding of quantitation using radiometric or LC/MS-based methods
• Experience operating liquid handlers and working with assay automation
• Experience working in the pharmaceutical industry or in a contract research organization (CRO)

Required Skills:

Drug Transport, In Vitro Cell-Based Assays, Mammalian Tissue Culture

Preferred Skills:

ADME, Automated Liquid Handling Systems, Liquid Chromatography-Mass Spectrometry (LC-MS), Radiometric Detection

Salary range for this role is $87,300.00 – $137,400.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. A federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.