Scientist, Radiochemistry Full-time NEW

Fusion Pharmaceuticals Job Post

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion's clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.

The Scientist, Radiochemistry role is an onsite, lab position in Hamilton, Ontario.

Responsibilities and Job Tasks

Responsibilities and job tasks (including, but not limited to):

• Effectively execute routine radiolabeling productions for a range of targeting moieties (small molecules to mAbs) and radioisotopes in support of biological studies as a part of the Discovery team
• Contribute to the preparation, purification and characterization of novel radioconjugates including stability assessments
• Assist in the synthesis of radiolabeling precursors as required
• Analyze and interpret data
• Maintain clear and current records of work within a laboratory notebook
• Contribute to the organization and maintenance of all chemistry laboratories including waste streams in collaboration with operations and health physics teams
• Effectively communicate scientific findings, which may come in the form of writing reports and presentations

Qualifications

Qualifications:

• B.S. required, M.S. desired with 2-5 years of relevant laboratory experience
• Driven radiochemist with a recognized post-secondary education in radiochemistry, inorganic chemistry, organometallic chemistry or a related discipline
• Experience with bioconjugations and medicinal synthetic chemistry is also desirable
• Experience in performing in vitro assays with radioconjugates is desirable
• Excellent troubleshooting skills in the lab, organizational skills and an understanding of the radiopharmaceutical field
• Experience with analytical HPLC method development and Empower software
• Proven ability to work independently with strong communication skills and attention to detail, including proficiency in the English language
• Demonstrable independent research accomplishments
• Excel at working in a fast-paced, collaborative environment as a member of a multidisciplinary team
• Knowledge of good laboratory practices is an asset
• Demonstrated ability to successfully prioritize tasks and manage timelines
• Experience in the safe handling and analysis of radiometal conjugates is desirable

Annual base salary for this position ranges from 82,377.60 to 108,120.60.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks' paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.