Senior Principal Scientist, Lab Head, Metabolism Drug Discovery Full-time NEW

Senior Principal Scientist, Lab Head

At Genentech, you'll be part of a team breaking new ground in pursuit of revolutionary medicines. The Metabolism Drug Discovery Unit (M-DDU) within Genentech Research and Early Development (gRED) is seeking a Senior Principal Scientist, Lab Head to lead our groundbreaking efforts in metabolic disease research. This is a key role responsible for making significant contributions to the early stage cardiometabolic pipeline, including obesity and its comorbidities.

The successful candidate will drive efforts spanning early target identification through clinical candidate advancement, while expanding disease-area biology. The Senior Principal Scientist will be able to work alongside world-class scientists, computational biologists, therapeutic engineers and clinicians across the Genentech/Roche organization. This position reports to a Group Leader / Distinguished Scientist in the M-DDU and offers the opportunity to build a lab team focused on key biological questions, drug pharmacology, and clinical translatability.

Key Responsibilities and Attributes of the Senior Principal Scientist:

• Lab focused and biology driven, building and managing a team of expert experimental biologists focused on metabolic disease biology, target and drug discovery.
• Conduct experimental biology, with their team, in support of disease biology, target discovery and validation.
• Apply expertise of biological pathways of metabolism, appetite regulation, energy homeostasis, nutrient flux and their dysregulation in disease.
• Establish and leverage experimental models of disease, including models applicable to genetic or drug screening, to more complex models that capture key aspects of human metabolic disease.
• Serve as biology lead in preclinical metabolism drug discovery programs, guiding the evaluation and development of novel therapeutics for cardiometabolic diseases including obesity and its comorbidities.
• Drive biology strategy through a practical understanding of drug discovery optimization and screening cascades, and a hands-on understanding of key biology experiments to conduct in support of go/no-go decisions.
• Partner closely with internal teams across departments and disciplines, including Drug Development, Translational Medicine, Computational and Clinical Science, to drive innovative therapeutic strategies, formulate new therapeutic hypotheses and advance transformative medicines.
• Communicate findings to internal meetings and governance boards, author documents including IND reports, and publish impactful scientific discoveries.
• Manage day-to-day lab operations, ensure best practices and compliance for ELN and documentation, and oversee external collaborations or outsourcing as needed.
• Foster a collaborative, high-performance team culture, mentor and motivate team, and provide career development for scientists and research associates.

Who You Are:

• PhD, MD, or MD/PhD in Metabolism, Cardiovascular Research, Neuroscience, Endocrinology, Physiology or a related discipline.
• Minimum 8-10 years post-Ph.D. of productive postdoctoral training and preferably industry experience.
• Proven track record of driving innovative research in metabolic disease.
• Strong hands on lab experience in the latest state-of-the-art techniques applied to metabolic disease research.
• Demonstrated impact through high-quality publications, patents, and/or successful program advancement.
• Expertise spanning basic and translational research focusing on metabolic disease including obesity, diabetes, cardiovascular disease, renal disease, heart disease, MASH, and related indications.
• Minimum of 5 years of direct managerial experience.
• Exceptional leadership potential and a track record of working with multidisciplinary teams, excellent written and verbal communication skills, and a collaborative spirit.
• Preferred Experience in human genetics
• Application of AI/ML based methodologies to biological research
• Hands-on experience with in vivo CVRM models and techniques

At Genentech, you'll work alongside world-class scientists in a culture that fosters creativity, innovation, and scientific excellence. Join us in our mission to develop life-changing therapies for patients with metabolic disorders.