Senior Principal Scientist – Process Chemist Full-time

Senior Principal Scientist – Chemist

Reporting to the Advisor – Chemist, the Senior Principal Scientist – Chemist will be responsible for supporting the advancement of radiopharmaceutical precursor programs from R&D through early phase clinical stages. The selected candidate will have deep technical expertise in organic synthesis, purification, and characterization techniques to support the development and manufacture of phase-appropriate precursors and related standards. The selected candidate will be comfortable working both independently as well as in collaboration with other departments and external partners to ensure successful development of novel precursor candidates in the RLT pipeline. This position will be within the Precursor team which is part of the Early Phase CMC group.

Responsibilities:

• Independently perform complex and diverse organic syntheses, purifications, and characterizations to provide radioligand precursors and related standards.
• Understand the physical and chemical properties of products, raw materials, intermediates, and reagents, with the ability to select appropriate reaction conditions with reference to literature.
• Design and plan expedient synthetic routes based on literature precedent.
• Conduct and interpret a wide variety of modern chemical analyses (e.g., NMR, HPLC, MS).
• Analyze technical data and documents, provide recommendations and planning for subsequent experiments.
• Support synthesis scale-up efforts and other technology transfer activities.
• Accurately record experiments and related data in accordance with GxP requirements.
• Maintain a safe and functional laboratory environment including but not limited to equipment maintenance, chemical inventory, and ordering and receiving chemicals and consumables.
• Ensure adherence to local Environmental, Health and Safety (EH&S) regulations, company policies, standard laboratory safety practices, and any other quality or regulatory requirements.
• Provide verbal and written reports and presentations as required in a clear and concise manner.
• In collaboration with managers and cross-functional teams, develop timelines and deliverables to accomplish project goals.
• Multi-task and prioritize project deliverables in a fast-paced environment.

Basic Requirements:

• Master's degree in organic chemistry, medicinal chemistry, organometallic chemistry or related field
• 2+ years of hands-on experience with all aspects of modern synthetic chemistry including designing and executing multi-step syntheses, purification techniques (e.g., chromatography, crystallization), and characterization techniques including HPLC, NMR, MS, etc.
• Demonstrated ability to work effectively in multi-disciplinary team settings and manage relationships with external partners and vendors
• Strong oral and written communication skills with ability to articulate complex scientific concepts clearly
• Strong scientific, analytical, and project management skills
• Proficiency with Microsoft 365 (Excel, Word, PowerPoint)
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Additional Preferences:

• PhD in organic chemistry, medicinal chemistry, organometallic chemistry or related field, post-doc experience
• Experience designing and working with metal chelators and radioligand chemistry is considered an asset.
• Experience working in a pharmaceutical GMP manufacturing environment with functional knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines is strongly preferred
• Ability to work effectively both independently and as part of a collaborative team.
• Excellent written and oral communication skills.
• Ability to execute with high attention to detail, strong organizational skills, and extreme sense of urgency.

Other Information:

• The physical demands of this job are consistent with a laboratory environment. The ability to lift heavy materials up to 20kg may be required.
• This role requires a 5 days on-site presence unless otherwise specified.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $ – $. Full-time equivalent employees may also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees.