Senior/Research Fellow, Immunology & Cell Biology [LKCMedicine] Full-time

Senior/Research Fellow In Cancer Immunity Translational Research

The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School, which offers both undergraduate and graduate programmes, is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University, Singapore, in partnership with Imperial College London, LKCMedicine aims to be a model for innovative medical education and a centre for transformative research. The School's primary clinical partner is the National Healthcare Group, a leader in public healthcare recognised for the quality of its medical expertise, facilities and teaching. The School is transitioning to an NTU medical school ahead of the 2028 successful conclusion of the NTU-Imperial partnership to set up a Joint Medical School. In August 2024, we welcomed our first intake of the NTU MBBS programme, that has been recently enhanced to include themes like precision medicine and Artificial Intelligence (AI) in healthcare, with an expanded scope in the medical humanities. Graduates from the five-year undergraduate medical degree programme will have a strong understanding of the scientific basis of medicine, with an emphasis on technology, data science and the humanities.

Key Responsibilities:

The appointed Senior/Research Fellow will lead studies on cancer immunity translational research. The successful candidate will have the opportunity to work in a dynamic research environment with access to state-of-the-art core facilities. The staff will:

• Perform experiments using cell-based assays, including isolation of T-cells from human blood and their culture, diverse range of mammalian cell lines, flow-cytometry analysis, microbiome analysis, and functional assays to better understand role(s) of specific metabolites or compounds in anti-tumor immunity, tumor initiation and progression.
• Collect clinical samples (mainly tumor biopsies, blood, and fecal samples with the help of clinician collaborators), and perform metabolomics profiling, and data analysis.
• Perform small animal experiments, including those utilizing humanized mice and fecal microbiota transplantation, and determine how certain microbes/metabolites regulate immune function in vivo.
• Work closely with the PI, Co-PIs and collaborators, document results, write reports, develop research proposals, and prepare manuscripts for scientific publications.
• Assist in the purchasing of laboratory materials and provide general support to the lab, such as keeping track of cell lines, plasmids and other reagents and materials, participate in lab health and safety measures, risk assessments, and attend regular lab meetings.
• Contribute to the overall development of competitive T-cell immunology translational research.

Job Requirements:

• Ideal candidate for Senior/Research Fellow should have a PhD in biological/biomedical sciences from a reputed University.
• Proficiency in standard cellular, molecular, imaging, and functional techniques. Experience in small animal handling would be an advantage.
• Significant scientific achievements, in terms of publications in reputed journals, patents, awards etc. from his/her PhD training and previous research.
• Fluent in English (written and spoken) with good communication and technical skills, self-motivated and well-organized.
• Willing to participate in routine laboratory management and maintenance, capable of independently working on multiple projects with minimum supervision, collaborate effectively in a highly diverse and interdisciplinary team and able to write manuscripts and research proposal.

We regret that only shortlisted candidates will be contacted.