Senior Research Fellow, Therapeutic target discovery [LKCMedicine] Full-time

Scientist To Lead Novel Therapeutic Target Discovery

The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School, which offers both undergraduate and graduate programmes, is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University, Singapore, in partnership with Imperial College London, LKCMedicine aims to be a model for innovative medical education and a centre for transformative research. The School's primary clinical partner is the National Healthcare Group, a leader in public healthcare recognised for the quality of its medical expertise, facilities and teaching. The School is transitioning to an NTU medical school ahead of the 2028 successful conclusion of the NTU-Imperial partnership to set up a Joint Medical School. In August 2024, we welcomed our first intake of the NTU MBBS programme, that has been recently enhanced to include themes like precision medicine and Artificial Intelligence (AI) in healthcare, with an expanded scope in the medical humanities. Graduates from the five-year undergraduate medical degree programme will have a strong understanding of the scientific basis of medicine, with an emphasis on technology, data science and the humanities.

The Nutrition, Metabolism and Health Programme is addressing one of the world's most pressing healthcare issue: Over nutrition driven chronic diseases. The key objectives are to support efforts to elucidating the molecular basis of type-2 diabetes, metabolic syndrome, including fatty liver disease and to track changes in inflammatory signatures and states from healthy to metabolically imbalanced phenotypes. Our mission is to understand the developmental and environmental basis of obesity, diabetes, related gut, liver and metabolic disorders and to translate this understanding into disease alleviation and prevention.

We are looking for a very experienced scientist to lead our novel therapeutic target discovery efforts. The role will focus on in vivo functional genomics to dissect metabolic syndrome related liver disease, identify and validate therapeutic targets, generating IP.

Key Responsibilities:

• Be an excellent team player and closely interact with physicians, bioinformaticians, industry partners as well as other researchers
• Conduct in vivo functional genetic screens using relevant mouse models
• Analyze screening data and identify high potential therapeutic targets
• Validate therapeutic targets in vivo in mouse models and in vitro in relevant human cell models
• Identify mode of action of therapeutic effect
• Supervise PhD, FYP and intern students
• Write IACUC protocols, grants and scientific articles
• Have extensive experience in mouse handling, cell culture, NGS & NGS data analysis, stem cell culture

Key Competencies and Educational Requirements:

• PhD degree in domain discipline or related field
• At least 10 years of relevant experiences in similar role / technical hands-on experience in mouse handling, in vivo functional genetic screens
• Familiarity with IACUC and health and safety regulations in Singapore
• Good written and oral communication skills
• Proficiency in mouse handling, HDTV, stem cell culture
• Competent in writing grants and scientific articles as well as working in a team
• Ability to work independently / develop solutions under strict timelines, meticulous and eye for details / excellent organizational / time management skills
• Leadership Competency as below:

• Ability to build rapport and influence stakeholders at all levels
• Ability to work collaboratively in a fast-paced environment.
• Possesses international experience