Senior Research Scientist, Chemical Biology & Proteomics Full-time NEW

Senior Research Scientist, Chemical Biology & Proteomics

We are seeking a highly motivated and talented scientist to join our Chemical Biology & Proteomics (CBP) team at AstraZeneca in Waltham, MA. As a Senior Research Scientist, you will be an integral member of a team generating pre-clinical pharmacology data to understand efficacy and selectivity of therapeutic agents. You will have the opportunity to work with a team of cross-functional scientists and support the development of new and successful therapies for patients. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Key Responsibilities

• Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas
• Develop mass spectrometry-based methods to conduct covalent screens
• Design and execute experimental plans to understand target engagement and selectivity profiles of therapeutic agents, understand drug-induced proteome dynamics and investigate post-translational modifications (PTM)
• Represent CBP team, and communicate with project discipline leads, and contribute to generation of mechanistic hypotheses through interpretation of sophisticated proteomics data
• Maintain and troubleshoot LC-MS system

Essential Requirements

• PhD with 2+ years of post-doctoral/industrial experience
• Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/or absolute protein quantification)
• Experience with mass spectrometry-based covalent screening, and proven expertise with IP-MS or chemical probe-based enrichment MS workflows, and experience developing automated processes to analyze large number of samples for MS analysis
• Skilled in investigating compound effects under biochemical and cellular settings with quantitative mass spectrometry, e.g. PTMs, protein complexes perturbations, etc
• Experience in determining protein abundance and turnover by using quantitative proteomics technologies, such as TMT, SILAC, and/or label-free approaches and data independent acquisition (DIA)
• Expertise in data analysis and an ability to communicate data interpretation clearly
• Significant external reputation gained through professional recognition, external presentations and publications in high-impact journals
• Ability to contribute with a positive, result oriented and problem-solving attitude

Desirable Requirements

• Experience in pre-clinical drug discovery
• Experience using Thermo Q-Exactive, Orbitrap Exploris, Eclipse, Astra Zoom or TimsTOF
• Experience with Xcalibur, Proteome Discoverer, MaxQuant, Skyline, Spectronaut and DB search engine tools
• Experience with liquid handling systems and robotic automation
• Familiarity with targeted proteomics is a plus

Why AstraZeneca?

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.