Senior Scientist Full-time

Senior Scientist Oncology Small Molecules

We are seeking a highly motivated and technically skilled Senior Scientist with a history of scientific excellence in in vivo pharmacology to join our Oncology Small Molecules team in Waltham MA, USA. As a Senior Scientist, you will be a technical lead delivering in vivo pharmacology data to support our oncology small molecules' portfolio, with a focus on drugs targeting solid tumor indications including Breast, Prostate, Lung, and Colorectal cancers.

Key Responsibilities:

• Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous and orthotopic xenograft models and Patient Derived Xenograft models.
• Designing and performing in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive high-quality in vivo pharmacology data packages to support early and late-stage drug discovery programs.
• Profiling tissue samples ex vivo to explore mechanisms of drug response and resistance using both traditional and novel approaches.
• Working collaboratively and cross functionally to develop and implement work plans and timelines.
• Working with IT programs, artificial intelligence, and databases to record all study data for broad access by project teams and partners.

Essential Requirements:

• BS in biology, pharmacology, or related field with a minimum of 6+ years, or MS with 4+ years, of hands-on in vivo experience.
• Advanced practical in vivo skills in the use of mouse models, as well as ex vivo analysis of mouse tissues.
• Ability to learn and apply new techniques and establish new disease models.
• Ability to work both independently as well as within project teams and across subject areas.
• Exceptional communication, listening and organizational skills. Ability to analyze, organize and present data to a diverse audience.
• Understanding statistical methods and quality control of data with the use of GraphPad Prism, Microsoft Office, and in vivo data capturing systems such as Study Log.

Desired Requirements:

• PhD with a minimum of 4+ years of hands-on in vivo experience.
• Industry experience in technical in vivo delivery to advance drug discovery/development.
• Experience measuring biomarkers and using ex vivo techniques such as IHC, Western blot, ELISA, Fluidigm, MSD-based platforms.

Why AstraZeneca?

At AstraZeneca, we embrace opportunities for change to drive meaningful advancements. Our mission is clear: to deliver life-changing medicines and redefine possibilities in biopharma. By combining diverse perspectives, pioneering science, and bold ideas, we are transforming patient outcomes worldwide.

The annual base pay for this position ranges from $108,473.60 to $162,710.40 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.