Senior Scientist, Biologics Design and Display, Discovery Biologics Full-time NEW

Senior Scientist

We are on a quest for cures and are committed to be the world's premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.

We are seeking a Senior Scientist to join Biologics Design and Display team in the Boston Discovery Biologics group. The successful candidate will be an integral member of the team responsible for conducting in vitro display campaigns to generate novel therapeutic hits and optimized leads. They will directly contribute to the discovery of novel biologics as well as platform build and technology optimization efforts. They will stay current with scientific progress and drive continuous innovation of display technologies to consistently deliver high quality early biologics to support drug discovery across multiple therapeutic areas. As part of project teams, they will collaborate across groups to solve complex problems in disease biology and drug discovery. They will attend scientific conferences, contribute to publications, train and mentor junior staff and interns, and help to set the group strategy.

We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission.

Responsibilities

• Perform yeast and phage display based biologics discovery screens to support therapeutic programs
• Execute display-based lead optimization, including display library building, QC, and screening
• Contribute to design and building of novel display libraries
• Routinely use NGS, including NGS library generation, QC, sequencing and data analysis, for hit selection
• Maintain accurate data and experimental records
• Prepare presentations to effectively communicate experimental results in team meetings
• Collaborate across different functional areas within Discovery Biologics and with key stakeholders in other departments
• Stay abreast of external advancements in the relevant scientific fields
• Promote the external reputation of our company's Discovery Biologics

Qualifications & Experience

• PhD in Biology, Biochemistry, Analytical Chemistry, Bioengineering, Biophysics, Protein Sciences, Pharmaceutics, or a related life sciences discipline with 0-3 years of experience or MS with >5 years of industry experience
• Expertise in using display-based screening methods
• Expertise in molecular biology and high throughput laboratory methodologies
• Strong presentation and publication record

Required Skills

• Deep expertise in both phage and yeast display
• Hands on experience in antibody or other molecular display technologies
• Expertise in NGS technology, including NGS libraries generation, QC, sequencing and sequence analysis
• Strong technical knowledge of molecular biology
• Strong analytical and problem solving skills
• Stay abreast of external advancements in the relevant scientific fields
• Excellent communication and organizational skills

Preferred Skills

• Hands on expertise in display library design and generation
• Knowledge of computational and structure-guided approaches in display library design
• Knowledge of antibody discovery technologies beyond display
• Hands on expertise in using laboratory automation

Required Skills: Antibodies, Antibody Discovery, Display Technologies, High-Throughput Screening, Molecular Biology Techniques, Next Generation Sequencing (NGS), Phage Display, Yeast Display

Preferred Skills: Automation

The salary range for this role is $119,100.00 – $187,500.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance.

Employee Status: Regular

Relocation: Domestic

VISA Sponsorship: Yes

Travel Requirements: No Travel Required

Flexible Work Arrangements: Not Applicable

Shift: Not Indicated

Valid Driving License: No

Hazardous Material(s): OEB4

Job Posting End Date: 02/10/2026

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