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Researcher / Scientist
Senior Scientist – Cell Surface Discovery Full-time NEW
Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Cell Surface Discovery
What You Will Do
Let's do this. Let's change the world. Amgen is seeking a passionate and innovative Senior Scientist to join the Functional Genomics teams in South San Francisco. This role is at the frontier of discovery biology, combining Discovery Genomic and Proteomic technologies to uncover novel therapeutic targets across Amgen's key therapeutic areas including Oncology, Inflammation, General Medicine, and Cardiovascular or Metabolic diseases.
The successful candidate will bring expertise in high-dimensional transcriptomic profiling and surface protein analysis as well as disease functional or screening modeling to support target identification, validation, and mechanism-of-action studies. You will play a key role in driving innovation, developing technologies, and integrating multi-omics approaches to advance Amgen's discovery pipeline.
Key Responsibilities
- Design, implement, and execute complex experimental workflows to profile cell surface proteins and full-length or translated transcriptomes.
- Lead and support single-cell genomics analysis and surfaceome-based target discovery projects using in vitro and ex vivo models (cell lines, organoids, tissues).
- Assist to develop and apply proximity labeling, cell surface enrichment, and related profiling efforts for functional genomics studies.
- Prepare high-quality samples for mass spectrometry (e.g., TMT, DIA) and next-generation sequencing.
- Use cutting-edge software tools (e.g., Cell Ranger, Seurat, Proteome Discoverer, Spectronaut, DIA-NN) and collaborate with bioinformatics to analyze and interpret high-dimensional datasets.
- Collaborate across multidisciplinary teams to drive integrated multi-omics discovery efforts.
- Present findings internally and externally through team meetings, conferences, and peer-reviewed publications.
- Maintain detailed electronic lab notebooks and experimental records.
What We Expect Of You
We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.
Basic Qualifications:
Doctorate degree
Master's degree and 3 years of relevant scientific experience or
Bachelor's degree and 5 years of relevant scientific experience
Preferred Qualifications:
- Expertise in single-cell RNA-seq technologies (10x Genomics platform, library prep, data QC/analysis).
- Expertise in data generation and analysis of short- and long-read sequencing platforms and proven experience with Ribo-seq or polysome-seq would be plus.
- Expertise in CRISPR-based editing technologies and overexpression systems (e.g., lentiviral delivery).
- Experience in developing and handling diverse biological sample types (e.g. primary cells, organoids, or IPS-derived models as well as FFPE or frozen tissues).
- Experience in high-throughput automation platforms (e.g., Agilent Bravo) would be plus
- Familiar well with antibody or protein engineering and proximity labeling platforms
- Track record of scientific innovation, publications, and/or conference presentations.
- Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams.
- Excellent verbal, written, and organizational skills.
What You Can Expect From Us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models, including remote and hybrid work arrangements, where possible