Senior Scientist, Computer-Aided Drug Design (CADD) – In Silico Discovery Full-time

Senior Scientist, Computer-Aided Drug Design (CADD) – In Silico Discovery

Johnson & Johnson Innovative Medicine (JJIM) is recruiting for a Senior Scientist, Computer-Aided Drug Design (CADD) – In Silico Discovery to join our Therapeutics Discovery team located in either San Diego, CA (La Jolla area) or Spring House, PA (Philadelphia area).

The Therapeutics Discovery organization within JJIM is continuing to build scientific expertise in modeling, screening, pharmacology and chemistry to partner closely with therapeutic area scientists to develop groundbreaking new medicines in the areas of Immunology, Neuroscience and Oncology. The In Silico Discovery (ISD) group in Therapeutics Discovery is seeking two excellent scientists to bring their expertise to exciting and novel areas of computational drug design.

Key responsibilities include:

• Design therapeutic molecules and calculate their properties using state-of-the-art methodologies integrating chemical, biological and structural data, cheminformatics, and artificial intelligence/machine learning techniques
• Serve as a scientific expert and to contribute in multi-disciplinary discovery project teams that include synthetic chemists, structural biologists, and other discovery scientists, by providing key computational expertise to advance drug discovery projects
• Collaborate within Janssen and with external academic and industrial partners to develop new computational technologies to address key questions in drug discovery
• Publish results in peer reviewed journals and present at scientific meetings
• Mentor junior scientists and/or interns fostering their development as expert computational drug hunters
• Contribute to efforts to evaluate and assess novel protein targets of interest for their ligandability and tractability against various modalities (small molecule, degraders, peptide, glues, etc.)

Qualifications:

• A PhD in computational chemistry, organic chemistry or a related field, with at least 1-5 years of experience applying computational modeling in a pharmaceutical industry drug design setting is required
• Excellent written and verbal communication skills, and a publication record is required
• Experience with multiple therapeutic modalities (e.g. small molecules, biologics, peptides, targeted protein degraders) is preferred
• Experience with one or more of: working in a cross-functional environment, mentoring scientists, influencing decisions and resolving conflicts is strongly preferred
• Familiarity with at least one standard computational drug discovery package (examples may include Maestro/Schrodinger, MOE/Chemical Computing Group, and/or OpenEye tools) is required
• Experience scripting computational workflows in Pipeline Pilot, KNIME, Python or Jupyter notebooks is preferred

This is a hybrid role available in Spring House, PA, or San Diego, CA within the US (no fully remote option). Travel up to approximately 10% may be required, domestic and international.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or internal employees may contact AskGS to be directed to your accommodation resource.