Senior Scientist, Cryo-Electron Microscopy Full-time

Senior Scientist, Cryo-Electron Microscopy

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Bristol Myers Squibb is seeking a highly motivated individual to manage operations of our new state-of-the-art electron microscopy suite featuring a Titan Krios G5 as part of the Structural Biology team in San Diego, CA. The candidate will support a collaborative group of protein scientists, structural biologists, computational scientists, and interdisciplinary collaborators across a range of research programs. A strong background in protein sciences or molecular biology is essential for effective communication and program impact. Candidates must have robust expertise in biological cryoEM workflows and structural biology, with proven ability to coordinate complex projects in an industry setting. The candidate will also facilitate integration with our New Jersey EM site by aligning workflows, maintaining consistent standards and data management across teams. The candidate should be well-connected to developments in the field and able to implement new EM technologies as they emerge. Scientific rigor, critical thinking, excellent communication, and creativity are required.

Responsibilities:

• Maintaining day-to-day operations of the San Diego cryoEM facility, including oversight of the sample preparation equipment, Krios G5 microscope, IT/data management, and ensuring optimal data quality and analyses.
• Maintaining close coordination with ThermoFisher Scientific service engineers and support teams to ensure optimal instrument performance, proactive maintenance, and rapid troubleshooting for the Krios G5 system and associated sample preparation devices.
• Training and mentoring scientists in single particle cryoEM sample preparation, data collection, and image analysis.
• Leveraging a strong foundation in protein sciences and/or molecular biology to communicate effectively with research scientists, support interdisciplinary collaboration, and drive program impact.
• Providing technical support and troubleshooting to facilitate protein structure determination for drug discovery projects, spanning soluble proteins, membrane proteins, glycoproteins, and other modalities.
• Coordinating EM workflows with the BMS New Jersey site to ensure alignment of scheduling, standards, and data management.
• Implementing, adapting, and optimizing single particle workflows in addition to developing and implementing new methodologies such as micro-ED and cryo-ET.
• Ensuring compliance with electronic lab notebooks, safety standards, and corporate policies.
• Interfacing with project leads in Disease Biology, Translational Research, Protein Sciences, Biophysics, and Computational-Aided Drug Design to enable structure-guided drug discovery research.
• Presenting project results and workflow innovations in cross-functional meetings, with a critical eye for both persuasive argumentation and collective progress.

Basic Qualifications:

• Bachelor's Degree with 7+ years of academic and/or industry experience
• Or
• Master's Degree with 5+ years of academic and/or industry experience
• Or
• Ph.D. or equivalent advanced degree in the Life Sciences, Chemistry, Biophysics or related stream with 2+ years of academic and/or industry experience

Preferred Qualifications:

• Ph.D. in Biochemistry, Structural Biology, Molecular Biology, or related discipline with 2+ years in laboratory-based research, ideally within an industry environment.
• Minimum 3-5 years hands-on experience operating and maintaining electron microscopes for biological studies, with particular emphasis on high-end cryoEM platforms (Krios, Talos, etc.).
• Demonstrated expertise in single particle cryoEM sample preparation, data collection, and image processing on a wide spectrum of biological specimens, including soluble and membrane proteins, glycoproteins, and complex assemblies.
• Track record supporting and troubleshooting biological and pharmaceutical projects; familiarity with medicinal chemistry and the drug discovery pipeline is strongly recommended.
• Experience coordinating multi-site workflows and balancing multi-project demands.
• Strong publication record demonstrating use of cryoEM to derive mechanisms of action.
• Excellent written and oral communication skills; highly organized and able to juggle multiple concurrent projects.
• Proactive in identifying operational inefficiencies and developing practical solutions.

Compensation Overview:

San Diego – CA – US: $131,590 – $159,454

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life benefits include:

• Paid Time Off
• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodations/adjustment prior to accepting a job