Senior Scientist, Downstream Full-time

Senior Scientist, Downstream Processes

Join Bristol Myers Squibb's dynamic Manufacturing Sciences & Technology (MS&T) laboratory team, where you will play a critical role in supporting commercial manufacturing and process technology transfer for biopharmaceuticals. As a Senior Scientist specializing in downstream processes, you will contribute your expertise in purification and primary recovery within a diverse, highly technical, and collaborative team of scientists and engineers.

The successful candidate will act as a subject matter expert and key contributor to the MS&T organization. MS&T scientists and engineers work across functional teams to achieve high-impact business objectives and ensure robust, compliant, and efficient manufacturing operations. This position offers significant exposure to partner functions including Manufacturing, Manufacturing Technology, Bioprocess Development, Quality Assurance, Analytical, and Global Regulatory Sciences.

Key Responsibilities:

• Lead downstream process support for commercial manufacturing and technology transfer activities.
• Provide technical input for process investigations, including root cause analysis and implementation of corrective and preventive actions (CAPAs).
• Drive continuous improvement initiatives to enhance process robustness, efficiency, and compliance.
• Support downstream activities for technology transfer, process validation, and preparation of Chemistry, Manufacturing, and Controls (CMC) documentation.
• Contribute to regulatory filings and interface with regulatory agencies, including support for inspections and responses to inquiries.
• Design and execute technical studies to support manufacturing investigations or technology transfer of new processes. This includes leveraging laboratory and scale-down models for:
• Protein chromatography
• Viral inactivation
• Viral filtration
• Ultrafiltration/diafiltration
• Membrane filtration
• Depth filtration
• Centrifugation
• Document and verify experimental data, interpret results in alignment with lab protocols and manufacturing processes, and generate comprehensive technical reports.
• Collaborate effectively with partners across MS&T, Manufacturing, Process Development, Quality, and Regulatory to align on technical strategies and execution.
• Evaluate emerging downstream process technologies and recommend improvements as appropriate.
• Demonstrate strong written and verbal communication skills to clearly convey technical data and conclusions.

Qualifications & Experience:

• Degree in Chemical/Biochemical Engineering, Biochemistry, or a related discipline:
• BS with at least 7 years of relevant industry experience
• MS with at least 5 years
• Ph.D. with 2–4 years
• Strong scientific understanding of protein purification and stability.
• Proficiency with downstream processing equipment and techniques, including:
• AKTA chromatography systems
• Ultrafiltration/diafiltration systems
• Experience with viral clearance processes is preferred.
• Demonstrated scientific curiosity, critical thinking, and collaborative problem-solving.
• Effective communicator with strong technical writing skills.
• Ability to operate in a regulated environment with understanding of GMP manufacturing impact, though laboratory work is performed in a non-GMP setting.

Compensation Overview: Devens – MA – US: $120,740 – $146,312. The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.