Senior Scientist I, Biologics Purification Full-time

Biologics Purification Scientist

Join AbbVie's Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity bispecific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).

Key Responsibilities:

• Lead the purification of bispecific antibody biologics to support critical research assays and studies
• Champion the selection, integration and application of advanced in silico tools to optimize complex protein separation
• Leverage Design of Experiments (DOE) with high throughput automation to evaluate and refine key process parameters to improve protein separation efficiency
• Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production liabilities and enable process scalability.
• Develop automated data capture workflows to enable AI/ML initiatives
• Collaborate with multidisciplinary teams, translating molecular insights into functional results
• Stay current with emerging scientific literature to foster innovation and continuous improvement
• Present findings clearly to diverse audiences and document results with rigor

Qualifications:

• BS, MS, or PhD in Bioinformatics, Biophysics, Chemical Engineering, or related field with typically 12+ years (BS), 10+ years (MS), or 4+ years (PhD) of experience
• Deep proficiency in large-scale bioprocessing, column chromatography, and automated liquid handling platforms
• Proven expertise applying computational tools and predictive modelling to support bioprocess development for bispecific antibodies
• Experience with DOE methodologies and application to multivariate analysis
• Skilled in software systems and/or programming languages, such as Unicorn, Empower, Python/CADET-Process, GoSilico, ASPEN Chromatography, Matlab, JMP, Minitab, Genedata Chromatics, or SDMS platforms
• Experience with data extraction API, ETL tools and LIMS platforms for data acquisition, integration, and management across multiple analytical platforms is a plus
• Strong understanding of molecular and post-translational attributes of biologics
• Exceptional analytical, communication, and presentation skills
• Collaborative spirit and dedication to scientific excellence

Why AbbVie? Here, we combine advanced science with our strong values, cultivating a culture where curiosity is encouraged and meaningful contributions are recognized. Grow your career, innovate boldly, and make a difference in the lives of patients around the globe.

Ready to pioneer the future of biologics? Apply and transform science into health at AbbVie.