Senior Scientist I/II, Analytical Chemistry – Particle and Material Analysis Full-time NEW

Senior Scientist, Physical Analytical Chemistry

AbbVie Analytical Research & Development (Analytical R&D) is a global analytical scientific organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative small molecule medicines and spans from the selection of Discovery candidate molecules to Late Stage Clinical. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies. We are looking for diverse candidates with strong scientific experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.

This Senior Scientist position will be in a technical specialty group – Physical Analytical Chemistry (PAC) within Analytical Structure Performance and Characterization (SPC) center. The PAC group is a global team of experienced and innovative scientists which utilize a diverse set of physical analytical tools to advance CMC development programs by providing insights and driving the understanding of materials, processes, and products. Additionally, the group contributes to development and justification of control strategies and authors relevant sections of regulatory submissions across all development phases.

The primary deliverables for this role are the application of physical analytical technologies in support of drug substance and drug product development, which include the design and execution of experimental studies and, when appropriate, the development of test methods. The primary area of focus is the application of particle characterization, solid form development, microscopy and imaging (optical, electron and X-ray) technologies and the development of insights driving deeper understanding of pharmaceutical materials, processes, and products. Other areas include the application of thermal analysis and/or vibrational spectroscopy.

Responsibilities:

• Utilize understanding of a range of physical analytical chemistry techniques to conduct research and development studies and route cause analysis related to pharmaceutical materials, processes, and products
• Support new product development with advanced methods development and validations, technical transfer packages, and generation of technical data in support regulatory requirements.
• Highly autonomous and productive in performing laboratory research, method development, problem-solving, requiring only minimal direction from or interaction with supervisor.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
• Process, interpret, and visualize data to facilitate project team decisions.
• Communicate and collaborate with cross-functional groups and departments.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and GxP compliance, where applicable.

Qualifications:

• Bachelors, Masters, or Ph.D. in Chemistry, Material Science, Pharmaceutical Sciences, or related field with minimum 10 (BS), 8 (MS), or 0-2 (Ph.D.) years related industry experience.
• Strong technical expertise in particle characterization including Laser Diffraction, Dynamic Light Scattering, Laser Obscuration, and Microscopic imaging (optical, SEM, micro CT, and Flow Imaging)
• Strong technical background in particle characterization, excellent problem-solving skills. Capable of independently developing and troubleshoot analytical methods.
• Experience with thermal (TGA, DSC) and spectroscopic analysis (PXRD, IR, Raman & fluorescence) is preferred
• Experience with post data collection processing, including 3D data reconstruction, artificial intelligence and machine learning strategies is preferred
• Experience with characterizing spray-dried material, peptides, LNPs, LAIs is preferred
• Ability to coordinate activities and work simultaneously on multiple projects, in a global, fast-paced, setting where priorities may change quickly.
• Proven effective written and verbal communication skills and ability to interact effectively with interdisciplinary scientists, engineers, quality staff, regulators, and management.
• High attention to detail and creative problem solving while exhibiting strong interpersonal skills and proven ability to work independently as well as part of teams
• Knowledge of instrument set-up, troubleshooting, management and maintenance.
• Experience extracting insights from multidimensional data sets, along with other physical analytical characterizations, and connecting to pharmaceutical materials, processes, and products
• Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.