Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development Full-time NEW

Senior Scientist

AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, identify and implement new methods and techniques, and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies.

Responsibilities:

• Lead research efforts, design and execute in vitro studies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development.
• Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
• Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
• Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
• Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
• Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
• Mentor and support junior scientists within the team.

Qualifications:

• BS, MS, or PhD in immunology, oncology, cell biology, molecular biology, biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0-3+ (PhD) years of experience.
• Expertise in mammalian primary cell and cell line culture (primary T cells, PBMCs, whole blood, suspension and adherent cell lines), multi-color flow cytometry (panel design, acquisition, and analysis), and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred.
• Experience with lentiviral vector design, production, and analytical characterization (e.g., titering, copy number analysis, transduction efficiency assessment) is highly preferred.
• Experience in evaluating vector biodistribution, transduction specificity, or safety-related parameters is a plus.
• Experience in CAR-T cell therapy and/or in vivo targeted delivery is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.
• Detail-oriented with a passion for delivering high-quality results.

Why AbbVie? AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

How to Apply: If you are passionate about advancing in vivo CAR-T therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position.