Senior Scientist II, Brain Transport Biology Full-time NEW

Senior Scientist

At AbbVie, we are dedicated to solving some of the world's most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. The Discovery Neuroscience In Vivo Pharmacology group in Cambridge, Massachusetts, is seeking a highly skilled and self-motivated Senior Scientist to join a dynamic team supporting target identification, validation, and drug transport facilitation over brain barriers. The successful candidate will drive scientific innovation, has experience making tangible contributions to the discovery pipeline, and has people and project management experience.

Responsibilities:

• Responsible for design and implementation of in vivo testing of multispecific biologics, small molecules, and siRNAs to support projects in the areas of Alzheimer's and Parkinson's disease
• Serve as an in vivo representative in cross-functional teams with Discovery Biotherapeutics, DMPK, and Development Sciences colleagues, providing project updates, analysis, and strategic advice
• Proactively translate department/project team scientific questions into well-designed experiments, utilizing internal and external resources
• Identify and solve technical problems independently, implement new assays and workflows, conceive and implement innovative research ideas
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions
• Collaborate with cross-functional partners at various AbbVie sites to advance candidates through discovery milestones
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor
• Mentor / matrix manage junior scientists, and be accountable for the effective performance of the team
• Ensure consistency and quality of technical reports
• Uphold impeccable research-related & corporate compliance standards
• May author or co-author peer-reviewed scientific papers or patents

Minimum Qualifications:

• Bachelor's Degree and typically, 12 years of experience, Master's Degree and typically 10 years of experience, PhD and typically 4 years of experience.
• Background in receptor and / or transporter biology and targeted delivery
• Background in brain barriers biology
• Experience with in vivo models of neurodegeneration, particularly with models of Alzheimer's and Parkinson's Disease
• Experience in assay development for target identification and validation, mechanism of action studies, biodistribution and biomarker analysis. Proven ability to troubleshoot and refine assays and workflows
• Proven track record in characterizing complex biotherapeutics in vivo (biologics, small molecules, siRNA)
• Proven track record of working in multidisciplinary in vivo pharmacology teams, demonstrated ability to collaborate effectively in a dynamic, cross-functional matrix environment
• Experience managing direct reports, including providing performance evaluations and development opportunities
• Excellent organizational skills, strong data analysis and critical thinking skills, and the ability to manage multiple projects simultaneously
• Goal-oriented and highly self-motivated team player with excellent verbal and written communication skills with experience contributing to technical reports and publications

Desired Qualifications:

• Experience operating effectively in a matrixed, fast-paced discovery organization
• Experience in managing external collaborations
• Experience with ex vivo readouts including immunohistochemistry and biochemistry (e.g., ELISA, WB, qPCR, ddPCR). Experience with image analysis
• Familiarity with CNS-relevant biology and genetic medicine applications

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our long-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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1. Yes, 5% of the Time

Pay Range: $109500 – 208500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.