Senior Scientist II, In Vivo Pharmacology (ON-SITE) Full-time

In Vivo Pharmacologist

Our In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated in vivo pharmacologist with experience in the development of biologic antigen-directed therapeutics (Antibodies, Antibody Drug Conjugates, etc.). This individual will support the in vivo strategy and coordination for various pipeline projects, and responsibilities will include tumor model selection, study design preparation, hands-on in vivo data collection, data analysis and presentation to project teams and stakeholders. The scientist will collaborate in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology agents through the preclinical R&D pipeline. The ideal candidate will be highly motivated, work independently, have excellent communication skills and previous industry experience in the oncology field.

Responsibilities include:

• Independently conceive and execute in vivo experiments utilizing human tumor models (CDX, PDX, orthotopic models) in immunocompromised mice.
• Strategize, design, execute and analyze in vivo data to assess the efficacy, PK and PD of novel therapeutics.
• Manage study operations within the team, including the coordination of study designs and timelines/resources.
• Critically evaluate scientific literature and external resources to identify innovative concepts, methods, or technologies and apply them effectively to solve problems and improve outcomes.
• Effectively collaborate across cross-functional teams, presenting research findings to project teams/governance bodies and preparing technical reports.
• Work with external contract research organizations to advance our understanding of oncology diseases.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Mentor and guide one or more scientists in the group, evaluating and ensuring their effective performance. People-management responsibilities will be dependent on previous experience.

Qualifications include:

• Bachelor's Degree or equivalent with 12+ years of experience, Master's Degree with 10+ years of relevant experience, or PhD with 4+ years of relevant experience. A degree in cancer biology, immunology, pharmacology, or a related discipline with extensive hands-on experience with in vivo tumor model execution. Drug development experience in a pharmaceutical or biotech industry setting is highly desired.
• Proficient hands-on experience with in vivo tumor model development, including tissue harvesting, tumor inoculation and dosing via different routes/sites (SC, IP, PO, IV).
• Extensive knowledge of oncology and tumor biology with a proven publication record.
• Excellent critical thinking skills to support efficient study planning and execution and troubleshooting.
• Proactive and able to manage multiple responsibilities, adapt to changing priorities and able to meet deadlines in a fast-paced environment.
• Excellent verbal and written communication skills and the willingness to work and build strong relationships with peers in a multidisciplinary team.
• Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

Additional Information:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.

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Pay Range: $109500 – 208500 USD

Where We Work

Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.