Senior Scientist, Investigative ADMET Laboratory Full-time

Investigative ADME, Toxicology, and Bio-Analytical Research Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

The Investigative ADME, Toxicology, and Bio-Analytical Research team focuses on drug discovery using innovative scientific approaches. We seek an experienced lab scientist to support and help develop our cross-site Investigative ADME Laboratory capabilities, including playing a substantive role to design, build, and deploy automation-friendly screening infrastructure. The candidate should have a passion and consistent track record for developing capacity enabling screening, mechanistic, investigative assays which deliver reliable results at the pace discovery research demands. Strong collaboration with ADME Project Leaders, lab-based scientists, and medicinal chemists is essential. This role requires excellent people and communication skills, a positive attitude, willingness and agility to learn, attention to detail, and the ability to thrive in a fast-paced team environment. The successful candidate will also be eager to apply emerging techniques in AI, agentic agents, and automation to their laboratory work and results.

Responsibilities:

• Maintain safety in the workplace as a primary priority
• Design, implement, and interpret in vitro ADME assays (metabolic stability, protein binding, reaction phenotyping, CYP inhibition/induction, transporter studies)
• Develop and validate novel assays to predict in vivo outcomes and address DDI assessments
• Generate data for PBPK modeling and collaborate with medicinal chemistry
• Operate LC-MS/MS instrumentation (Sciex/Shimadzu platforms) for quantitative/qualitative analysis
• Partner with CROs to design studies and interpret outsourced data
• Present findings, author technical reports

Minimum Qualifications:

• BS with 8+ years similar experience) within the pharmaceutical sector or related field.
• Experience in vitro ADME assay design, execution, and interpretation
• Experience with LC-MS/MS platforms and data analysis software (i.e. Sciex and Shimadzu platforms, Analyst software)

Additional Preferences:

• MS with 5+ years academic/research/industry experience Proven track record of delivering high-quality data in fast-paced, deadline-driven environments
• Strong communication skills and ability to work effectively in cross-functional teams
• Familiarity with CYP induction, transporter studies, and mammalian cell culture
• Understanding of ICH guidelines and regulatory ADME requirements
• Adaptive and applies creative problem solving to meet emerging needs
• Knowledge of IVIVE and PBPK modeling applications
• Self-driven and data-dependent decision maker