Senior Scientist, Radioconjugate Full-time

Senior Scientist – Radiopharmaceutical Development

At AstraZeneca, we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030, there is no better place to make a difference in medicine, for patients, and in society.

Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration, and we are always committed to lifelong learning, growth, and development. As part of our team, you'll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca, where your work will have a real impact on improving people's lives.

This is a 100% on-site role based in our lab in Hamilton, Ontario.

About the Opportunity

Are you ready to make a significant impact in the field of cancer research? We are looking for a dynamic and independent Senior Scientist with a passion for radiopharmaceutical development to join our radioconjugate portfolio team in Hamilton, Ontario, Canada. This role requires a proven track record of scientific excellence and project leadership experience. As a Senior Scientist, you will be the tumor biology technical lead for emerging radioconjugate programs, collaborating with internal teams and external partners to advance novel targeted alpha therapies. This laboratory-based position involves study design, hands-on execution, data analysis, interpretation, and cross-functional communication. You will lead preclinical pharmacology studies and support in vivo evaluations, generating decision-ready data packages to drive preclinical development forward.

Accountabilities

• Serve as an independent technical lead for radioconjugate programs, collaborating with cross-functional teams and external partners to generate critical program data for project milestone decisions.
• Stay up-to-date with technical, intellectual, and scientific expertise in tumor biology and cancer modeling, particularly related to targeted radioconjugates.
• Lead preclinical pharmacology studies, including radioligand binding, internalization, and retention assays.
• Support in vivo biodistribution, imaging, and efficacy evaluations.
• Plan and conduct in vitro studies and support in vivo studies to generate decision-ready data packages.
• Analyze and present results to core project teams, prepare materials for governance interactions, and deliver program updates across internal forums.

Essentials Skills and Experience

• PhD Degree with 3+ years of experience, Master's Degree with 5+ years of experience, or a Bachelor's Degree with 7+ years and project leadership experience in a relevant discipline related to tumor and radiation biology
• Demonstrates a strong knowledge of cancer/cell biology, radiation biology, and/or biochemistry in the context of cancer, with a robust desire for continued learning
• Expertise in routine cell culture, particularly culture of tumor cells Expertise in molecular- and cell-based methodologies, such as cloning/gene editing, cytotoxicity assays, binding and internalization assays, flow cytometry, ELISA, and Western blotting
• Works independently with minimal supervision to conduct experiments, analyze data, and prepare results for internal and external presentations and regulatory filings
• Excellent communication, presentation, and interpersonal skills evidenced by a history of successful project delivery in team-oriented, collaborative environments
• A proven track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals
• Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Desirable Skills and Experience

• Demonstrated proficiency in targeted radiopharmaceutical therapies and/or imaging, and a broad, up-to-date understanding of the field is highly preferred
• Prior experience in the biopharmaceutical industry and familiarity managing data delivery through contract research organizations preferred
• Demonstrated ability to coordinate project activities and provide scientific mentorship to junior scientists is highly preferred
• Direct, hands-on experience in residualization & saturation binding assays, radioimaging (PET or SPECT), biodistribution studies, non-clinical dosimetry, and other pre-clinical radiopharmaceutical methods is highly desirable
• Experience with targeted alpha emitter therapeutics is an asset

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com.