Sr. Principal Scientist / Advisor – Cryo-EM Full-time

Cryo-Electron Microscopy Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Lilly is seeking a highly motivated and skilled Cryo-Electron Microscopy Scientist to join our team. In this role, you will be responsible for executing and coordinating a wide range of experimental activities within the Cryo-EM facility. You will independently perform advanced laboratory techniques and support all stages of the Cryo-EM workflow – from sample preparation to data acquisition and analysis. Your contributions will directly support drug discovery efforts and technology development, advancing our ability to study biological systems at high resolution.

Key Responsibilities

• Operate, calibrate, and maintain high-end cryo-EM instrumentation
• Prepare cryo-EM samples
• Acquire high-resolution cryo-EM data
• Support negative staining sample preparation
• Perform image processing and structural analysis
• Collaborate with cross-functional teams
• Stay current with advances in cryo-EM
• Document experimental procedures
• Coordinated instrument maintenance
• Manage purchasing and inventory

Required Qualifications

• PhD in Structural Biology, Biophysics, Biochemistry, or a relevant scientific field is required OR Bachelors / Masters and 5+ years in the pharmaceutical industry
• Hands-on experience in cryo-EM data collection, image processing, and model building
• Experience with cryo-EM software tools

Preferred Qualifications

• Strong understanding of protein biochemistry and sample preparation techniques
• Excellent problem-solving skills and attention to detail
• Strong communication and teamwork abilities
• Experience working in a core facility, CRO, or industry setting
• Knowledge of small-molecule ligand fitting or fragment screening by cryo-EM
• Knowledge of HPLC and UHPLC instrumentation and use
• Experience with cryo-electron tomography (cryo-ET), including data acquisition and analysis

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $122,250 – $195,800. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees.