Sr Principal Scientist/Principal Scientist Full-time

Sr Principal/Principal Scientist In Discovery Toxicology

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

A position is available for an Sr Principal/Principal Scientist in Discovery Toxicology (DT) within the Pharmaceutical Candidate Optimization (PCO) organization at Bristol Myers Squibb. The incumbent will have responsibilities to identify and address toxicology issues across discovery programs that inform on program advancement, optimization of lead candidates and progression into development. The candidate will have demonstrated experience leveraging computational toxicology tools and big data analytics to generate mechanistic insights and guide decision making in safety assessment. Scientists in DT work with biology, chemistry and biotherapeutics representatives along with integrating across the other disciplines in PCO, namely drug metabolism and pharmacokinetics and pharmaceutics and bioanalytical sciences to ensure that quality drug candidates are advanced into development. The DT scientist is expected to serve as a core discovery team member and to provide actionable insights related to target and compound safety, as well as other critical attributes of drug candidates.

Responsibilities:

• Design, execute, interpret and report toxicology studies for evaluating potential toxicity of new drug targets, including new approach methodologies, within drug discovery and communicate these results across multiple disciplines and governance bodies
• Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or use of statistical programming to analyze large biological datasets, including transcriptomics and proteomics, for the investigation of mechanisms of toxicity
• Apply appropriate models and testing strategies to elucidate mechanisms of toxicity, assess human relevance, and design tools for proactive evaluation and prediction of liabilities associated with new drug entities
• Participate in drug discovery teams as a toxicology expert including communication of issues, experimental strategies for resolution and interpretation of results
• Discuss and enable transition of drug candidates into the BMS Development organization
• Contribute to the collective research expertise in DT including laboratory efforts to advance new tools and innovation in mechanistic toxicology research

Required Qualifications:

• PhD with 6+ years of academic / industry research experience in toxicology, or a closely related field
• Experience with computational toxicology approaches (e.g., in silico modeling, predictive toxicology, cheminformatics) and/or large-scale data analysis, including machine learning, and ability to translate findings into actionable insights on safety for drug discovery programs
• Versed in computational methods, with the ability to identify and evaluate emerging computational trends, and make informed recommendations on their adoption to support early toxicology risk assessment strategies
• Ability to generate thorough toxicology target liability assessments for proposed drug discovery targets, including providing suggested approaches and whether proactive follow-up is warranted based on weight of evidence
• Strong communication skills, both verbal and written, are essential. Additionally, the successful candidate is expected to be able to work in a highly collaborative manner with an enterprise mindset and patient-focused values

Preferred Qualifications:

• A Ph.D. in toxicology or a closely related field, along with 6+ years of postdoctoral and pharmaceutical industry experience in drug discovery is preferred
• A broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity
• Experience collaborating with computational teams and interfacing with IT to develop innovative approaches, enhancing toxicology prediction capabilities within the organization
• Practical experience with organoids, microphysiological systems or other new approach methodologies
• Experience in systems pharmacology or metabolism-mediated toxicity
• Strong and demonstrable skill set in design and implementation of mechanistic toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic or translational toxicology studies. The ability to design in vivo studies across species is also desired

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview: Cambridge Crossing: $182,160 – $220,729 Princeton – NJ – US: $158,390 – $191,930 San Diego – CA – US: $174,230 – $211,129 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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