Sr Principal Scientist, Translational Science Full-time

Principal/ Senior Principal Scientist, Translational Science

Are you driven by the opportunity to bridge preclinical and early clinical proof of concept studies? As a Principal Scientist / Senior Principal Scientist in Translational Science, you will work closely with translational leads to support biomarker identification and assay development activities. This role is highly collaborative, working across multidisciplinary teams to deliver impactful scientific insights.

In this role you will…

• Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays, including ELISA-based and flow cytometry-based readouts.
• Utilise your expertise in immunology to assist in the design, optimisation, and conduct of in vitro and ex vivo translational assays using primary human cells and tissues.
• Apply expertise in multiple capabilities such as flow cytometry, ELISA/MSD/Luminex, gene/protein expression analysis, cell and tissue imaging, proteomics, and other omics platforms.
• Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design.
• Present findings to internal teams, stakeholders, and governance in a clear and precise manner while maintaining accurate and detailed laboratory records to ensure compliance with data integrity expectations and safety guidelines.
• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and ensure compliance with all applicable laws, regulations, and ethical standards.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• PhD (or equivalent experience) in Cell Biology, Molecular Biology, Immunology or related field with extensive relevant laboratory experience.
• Expertise in primary cell culture as well as at least one of the following techniques: multi-colour flow cytometry, gene expression analysis, immunoassays (ELISA, MSD or Luminex).
• Ability to understand, interpret, and communicate complex scientific data
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Excellent record keeping and organisational skills.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Expertise in the development of ELISA-based and flow cytometry-based biomarker assays.
• Background and expertise in autoimmune and immune-mediated diseases.
• Previous experience in pharma or biotech industry; understanding of drug discovery processes including small and large molecule development.
• Experience processing human biological samples, developing B cell, T cell and myeloid cell functional readouts, flexibility to adopt new technologies.
• Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

Closing Date for Applications – October 6th 2025

Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391. The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.