Sr. Scientist, Analytical R&D Full-time

Senior Scientist (Protein & Enzyme Analytics) – Data Rich Measurements

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.

As a Senior Scientist in Analytical Enabling Capabilities, you will work with a highly collaborative team to advance the development pipeline. You will be primarily responsible for developing analytical methods for complex small molecules, peptides, oligonucleotides, protein-based therapeutics, and emerging modalities in our portfolio. You will work side by side with process chemists to deploy innovative technologies and analytical workflows for high-throughput analysis and characterization across fast-paced laboratory settings (Method Discovery, Protein Engineering, Biocatalysis). As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.

Education Minimum Requirement:

• PhD in Chemistry or a related field OR
• Masters in Chemistry or related field with 5+ years of experience OR
• Bachelors in Chemistry or related field with 8+ years of experience

Required Experience and Skills:

• 3+ years of thorough understanding of chromatography and mass spectrometry within method development.
• Creative problem solving in scientific research
• Excellent written and verbal communication
• Strong track-record of innovation translated into high impact factor publication
• Bioanalytical techniques, separations and python coding
• LC/MS analysis of proteins/enzymes, HDX-MS and high-throughput analysis
• Enzyme kinetics

Preferred Experience and Skills:

• Expertise in method development and troubleshooting of high-throughput fast chromatographic methods including reversed phase, ion exchange, size exclusion chromatography, etc.
• Hands-on experience in protein characterization techniques such as intact mass analysis, native-MS, peptide mapping analysis for the identification of PTMs, HCPs and disulfide mapping
• Strong understanding of designing and executing enzyme kinetics and functional activity assays
• Willing to learn new technologies and automation

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Required Skills: Accountability, Adaptability, Analytical Method Development, Anion Exchange Chromatography, Assay Development, Bioanalytical Analysis, Biochemical Assays, Cell-Based Assays, Chromatographic Techniques, Column Chromatography, Communication, Enzyme Kinetics, Gas Chromatography-Mass Spectrometry (GC-MS), GMP Environments, Healthcare Innovation, Innovative Thinking, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry (MS), Nuclear Magnetic Resonance (NMR) Analysis, Process Analytical Technology (PAT), Protein Engineering, Proteomics, Scientific Research, Spectrometry

Preferred Skills:

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

The salary range for this role is $117,000.00 – $184,200.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status: Regular

Relocation: Domestic

VISA Sponsorship: Yes

Travel Requirements: No Travel Required

Flexible Work Arrangements: Not Applicable

Shift: Not Indicated

Valid Driving License: No

Hazardous Material(s): N/A

Job Posting End Date: 02/20/2026

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