Sr Scientist, Non clinical Bioanalysis Full-time

Sr Scientist, Non Clinical Bioanalysis

This is a fully onsite role based at our customer's site in Cambridge, MA. We welcome applicants from all locations within the US. Must be legally authorized to work in the United States without sponsorship. Must be able to pass a comprehensive background check, which includes a drug screening.

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life – enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits. Location: 100% onsite in Cambridge, MA

The non-clinical bioanalytical team at our client site is searching for a Sr Scientist to join the team, developing, running and overseeing custom bioanalytical assays for research and development purposes. Assay applications will include pharmacokinetic (PK) assays in a non-regulated setting using mass spectrometry and immunoassay. This is a dynamic role where this lead scientist will get to wear multiple hats in discovery bioanalysis.

Key Responsibilities:

• Be a pioneer in setting up bioanalytical workflows through scientific acumen, relation building and efficient execution on goals.
• Design, develop and qualify PK assays in preclinical setting.
• Work on simple or complex biologics, and oligonucleotide bioanalysis
• Develop sample preparation approaches such as protein precipitation, solid phase extraction, Immunoprecipitation, enzymatic digestions etc.
• Develop LC-MS/MS and LC-HRMS for intact protein analysis, middle-up approach or bottom-up approach.
• Develop immunoassay methods using techniques such as MSD, SIMOA, Gyros etc.
• Coordinate outsourcing activities at CRO by monitoring method development, qualification and sample analysis by LC-MS and LBA.
• Use these methods to characterize pharmacokinetic profile of constructs, including integrity analysis.
• Participate in project team discussions and provide bioanalytical inputs to drug discovery efforts.
• Report and discuss bioanalytical results with integrative knowledge of how the data contributes to the drug development process.
• Actively contribute to scientific discussions.

Basic Qualifications:

• Has a Ph.D. in biochemistry, biotechnology, pharmaceutical sciences or related health sciences.
• 0- 2 years of experience working in a bioanalytical lab.
• Expertise in various mass spectrometry platforms, including high resolution mass spectrometry (time of flight and orbitrap) and triple quadrupole mass spectrometry
• Good understanding of protein analysis on platforms such as Thermo, Waters, Sciex.
• Experience with different extraction techniques for quantitation of proteins in biological matrices (plasma and tissues).
• Knowledge of proteomics tools such as handling queries on protein databases and protein sequence analysis.
• Preferred to have working experience on ligand binding assays.
• Ability to present and write scientific documents, including project team documents, study reports, posters and scientific publications.
• Ability to identify solutions to challenges scientifically and through inter-personal skills.
• Scientific curiosity, appetite for teamwork and problem-solving skills

Preferred Knowledge, Skills, and Abilities:

• 1- 2 years of experience working in a bioanalytical lab within a CRO
• Maintaining e-lab notebook
• Knowledge of proteomics tools such as handling queries on protein databases and protein sequence analysis.

Working Environment:

• Below is listed the working environment/requirements for this role:
• Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
• Able to work upright and stationary and/or standing for typical working hours.
• Able to lift and move objects up to 25 pounds
• Able to work in non-traditional work environments.
• Able to use and learn standard office equipment and technology with proficiency.
• May have exposure to potentially hazardous elements, including potentially infectious agents, typically found in healthcare or laboratory environments.
• Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!