Sr Scientist – Obesity Full-time

Join Amgen's Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr Scientist – Obesity

What You Will Do

Let's do this. Let's change the world. Amgen's Cardiometabolic Disorders Department is seeking a highly motivated and innovative Senior Scientist to join our research team focused on discovering and advancing novel therapeutics for obesity and related cardiometabolic diseases. In this vital role you will have a unique opportunity to lead preclinical biology efforts in a dynamic, cross-functional drug discovery environment.

Lead Preclinical Drug Discovery Effort : Act as the primary biologist on cross-functional drug discovery teams, driving the progression of programs from early research through candidate selection. Operate independently in a collaborative and fast-paced setting to support strategic goals.

Experimental Design and Execution : Design and perform in vitro experiments using diverse molecular and cellular biology techniques. Expertise should include, but not limited to:

• Primary and stable cell line culture
• Development of functional cell-based assays
• CRISPR/Cas-mediated genome editing
• Immunoassays (Western blot, ELISA, flow cytometry)
• RT-qPCR
• Fluorescence microscopy, and cellular imaging platforms

Cross-Functional Collaboration : Partner closely with in vivo pharmacologists, protein biochemists, structural biologists, medicinal chemists, computational biologists, pathologists, and mass spectrometry experts to inform experimental design and data interpretation.

Innovation and Scientific Rigor : Contribute to the development and application of cutting-edge technologies. Proactively propose and explore novel hypotheses to uncover new therapeutic opportunities in obesity and cardiometabolic diseases.

Communication and Dissemination : Present research findings to internal teams and at external conferences. Contribute to the preparation of scientific publications, patents, and regulatory documents.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]

Or

Master's degree and 3 years of directly related experience

Or

Bachelor's degree and 5 years of directly related experience

Preferred Qualifications:

• 5-8 years of wet lab experience in signal transduction, cell biology, cell metabolism, neurobiology, in vitro pharmacology, and/or related areas.
• Deep technical expertise in signal transduction, metabolic regulation, and/or in vitro pharmacology.
• Demonstrated creativity and scientific rigor, evidenced by first-author publications in high-impact peer-reviewed journals
• Strong understanding of the biology and genetics underlying human obesity and metabolic diseases
• Experience in the design and interpretation of studies involving rodent disease models and analysis of biological specimens
• Excellent written and verbal communication skills, with the ability to convey complex scientific concepts clearly and persuasively
• Proven ability to mentor junior scientists and effectively lead collaborative research efforts
• Passionate about developing transformative medicines for obesity and its complications

What You Can Expect From Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply Now And Make A Lasting Impact With The Amgen Team

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Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.