Sr Scientist – Product Development Full-time NEW

Product Development Scientist

Introduction to role:

Are you passionate about innovation and committed to advancing transformative therapies? As a proud new member of the AstraZeneca group, EsoBiotec is setting new standards in pioneering biotechnological research. With a shared vision to transform the future of medicine, our partnership leverages AstraZeneca's global reach and rich heritage in scientific innovation, amplifying EsoBiotec's unique culture of creativity and breakthrough advances in cell-based therapies and immunology. At EsoBiotec, now backed by the resources and expertise of one of the world's leading biopharmaceutical companies, you'll find a dynamic, collaborative environment where scientific passion drives real-world impact. Be part of a team where your work will contribute to shaping the next generation of life-changing treatments and help us push the boundaries of science to improve patients' lives worldwide. We are looking for an inspiring product development scientist to drive the development of our pioneering lentiviral therapies. Join our mission-driven team and help shape the future of cell and gene therapy with your expertise in product development. We value diverse perspectives and a collaborative, growth-minded approach.

Accountabilities:

• Independently design, plan and execute research development studies to generate high-quality data packages supporting regulatory filings.
• Plan and execute in vitro characterization and mechanism of action studies for new in vivo lentiviral delivery vector candidates.
• Evaluate lentiviral vectors and in vivo engineered cells in humanized mice models of disease with external animal testing service provider.
• Coordinate studies with other members of the team and external partners, analyze and present data internally to advance work packages for regulatory filings.
• Compile and validate study reports to support the nonclinical IND sections.
• Maintain accurate, detailed, and timely documentation in electronic lab notebooks.
• Prepare scientific summaries, internal reports, and presentations for internal governance and external stakeholders when required.

Essential Skills/Experience:

• MSc or PhD degree in Immunology or molecular and/or Cell Biology with 3-5 years industry experience (8-10 years for MSc) in in vivo and/or in vitro pharmacology development of immunotherapies, strong preference for CAR-T/TCT-T cell therapies.
• Previous experience with designing and executing pivotal non-clinical studies and authoring sections/reports for regulatory submissions is a must.
• Strong scientific/technical writing and communication skills in English is required.
• Strong interpersonal and communication skills. Proven record of collaborating and working effectively with internal and external partners.
• Excellent communication skills both written and oral in English is a must.
• Ability to multi-task in a fast-paced environment while meeting objectives.
• Autonomous, must be able to work independently with minimal supervision.
• Should be self-motivated, detail oriented, flexible, and have a “do-what-it-takes” attitude.

Desirable Skills/Experience:

• Direct experience with CAR-T/TCR-T cell engineering and characterization is preferred.
• Experience with humanized mice, disease modelling in mice for oncology and/or immune disorders and pre-clinical assessment of CAR-T/TCR-T cell therapies are preferred.

At AstraZeneca, we are driven by a bold ambition to eliminate cancer as a cause of death. Our team dedicated to Oncology is united by this vision, pushing forward with cutting-edge science and technology to achieve breakthroughs. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we are empowered to lead at every level, taking smart risks that write the next chapter for our pipeline. Join us in a place built on courage, curiosity, and collaboration where you can build a rewarding career committed to improving the lives of millions of people with cancer.

Ready to make an impact? Apply now to join our mission-driven team!