Sr. Scientist, Radiopharmaceutical Development Full-time NEW

Sr. Scientist, Radiopharmaceutical Development

Working with us: Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

The Sr. Scientist, Radiopharmaceutical Development is a leading contributor in the design, development, and advancement of RayzeBio's radiopharmaceutical programs. This senior role is responsible for driving innovative research in novel isotope and chelator development, translating cutting-edge scientific discoveries into robust clinical drug products. The Sr. Scientist will lead CMC radiopharmaceutical process development, oversee IND-enabling activities, and play a pivotal role in clinical manufacturing. This position demands expertise in radiochemical synthesis, analytical techniques, and radiopharmaceutical formulation, as well as a proven ability to manage complex projects and mentor junior staff.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Process Development & Scale-Up: Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards.
• Technology Transfer: Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites.
• Laboratory Oversight: Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure.
• Collaboration: Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs.
• Lead Research Initiatives: Independently design and execute advanced radiochemistry and radiolabeling experiments.
• Technical Leadership: Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies.
• Innovation in Isotope and Chelator Chemistry: Direct research into the identification, synthesis, and characterization of novel isotopes and chelators.
• Safety & Compliance: Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials.
• Data Analysis & Reporting: Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings.
• Project Management & Mentorship: Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates.
• Documentation: Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports.
• Travel: Less than 10% travel required.

Education and Experience

• BSc +7 years, MSc + 5 years or PhD +3 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience.
• Demonstrated expertise in radiochemical synthesis, purification, formulation, and analytical techniques.
• Proven track record of innovation in radiopharmaceutical development.
• Deep familiarity with federal and state regulatory requirements and safety protocols for radioactive materials.

Skills and Qualifications

• Advanced experience developing stable radiopharmaceutical formulations.
• Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems.
• Extensive experience with a broad spectrum of radioactive materials.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Physical Demands

While performing duties, the employee is regularly required to sit, reach with hands and arms, and talk or hear. Occasional lifting and/or moving up to 30 pounds may be required. Specific vision abilities include close and distance vision. Lab work requires use of protective clothing, gloves, and safety glasses.

Laboratory environment with moderate noise levels; strict adherence to safety protocols for working with radioactive materials is required.