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Postdoctoral Fellow
Computational modeling and high-density microelectrode array analysis forne Full-time
RESEARCH FOCUS
The Ben-Shalom laboratory investigates neurodevelopmental disorders (NDDs) using a multiscale approachintegrating high-density microelectrode array (HD-MEA) recordings with biophysically detailed computationalmodeling. Our research focuses on understanding how genetic mutations alter neuronal excitability and networkdynamics, leading to epilepsy and other NDDs. The candidate will develop and validate in silico neuronal modelsusing empirical data from HD-MEA recordings to bridge single-neuron biophysics with circuit-level dysfunction andidentify therapeutic targets.
RESPONSIBILITIES
Computational Modeling: Develop biophysicallydetailed neuronal models using NEURON, NetPyNE,and Python/MATLAB
HD-MEA Data Analysis: Process HD-MEArecordings including spike sorting and networkcharacterization
Model Validation: Integrate experimental data tovalidate computational models
Network Simulations: Simulate cortical networks topredict mutation effects and identify therapeuticinterventions
Data Integration: Combine multi-scale data withcomputational predictions using statistical and MLapproaches
Research Dissemination: Prepare manuscripts andpresent at conferences
QUALIFICATIONS
Ph.D. in computational neuroscience, biophysics,bioengineering, or related field
Essential: Experience with computational neuronalmodeling (NEURON, NetPyNE, or similar)
Highly Preferred: Experience with microelectrodearray data analysis and spike sorting
Strong programming skills in Python, MATLAB,and/or C++
Familiarity with ion channel biophysics and Hodgkin-Huxley modeling
Experience with large-scale data analysis andstatistical methods
Knowledge of machine learning approachespreferred
Excellent communication skills and ability to work inteams
RESEARCH ENVIRONMENT
Join a dynamic, collaborative laboratory at UC Daviswith state-of-the-art HD-MEA recording systems, patch-clamp electrophysiology, and high-performancecomputing resources.
Access to cutting-edge HD-MEA technology
Collaboration with experimental neuroscientists,clinicians, and computational researchers
Training in advanced electrophysiological techniquesand organoid culture
Professional development through conferences andgrant writing
Mentoring opportunities with graduate students andpostdocs
APPOINTMENT DETAILSCompetitive salary commensurate with NIH postdoctoral scales and experience. Excellent career development opportunities with potential for renewal based on performance and funding. Review of applications begins immediately and continues until filled.