Postdoctoral fellow in human immunology Full-time

The Locci lab studies T cell-B cell collaborations in health and disease. Areas of active investigation in the lab include T follicular helper (Tfh) cell differentiation and regulation of B cell responses in vaccination, infection and autoimmunity in mice and humans. The Lab is part of the Institute for Immunology and Immune Health (I3H), a large and vibrant immunology community at the University of Pennsylvania (Philadelphia, USA).

We are seeking a motivated and talented postdoctoral researcher to lead a project aimed at dissecting Tfh and B cell responses to SARS-CoV-2 in Long COVID, using combined approaches including single-cell transcriptomics (CITE-seq) and spatial transcriptomics on lymph node samples. Qualified applicants should have a PhD or an MD, and experience with human immunology and CITE-seq. Previous experience with spatial transcriptomics and bioinformatic skills are highly desirable.

Publications highlighting previous work from our group are:

• IL-12 drives the differentiation of human T follicular regulatory cells. Castano et al. Science Immunology 2024

• Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses. Bettini et al. bioRxiv 2024

• Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Lederer et al. Cell 2022

• Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh et al Immunity 2021

Tagged as: Life Sciences