Postdoctoral Associate Position at University of Pittsburgh Full-time

Position Summary

The Wang Laboratory  in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh seeks a highly motivated Postdoctoral Associate to lead innovative projects dissecting cancer signaling pathways and developing targeted therapeutics, with a particular focus on prostate cancer, and to contribute to other related collaborative efforts, including work in cerebrovascular biology/stroke.

About the Lab

We investigate how dysregulated signal transduction drives cancer initiation, progression, and therapy resistance. Our team integrates molecular and cellular biology with functional genomics and translational models to identify druggable nodes and guide mechanism-based interventions.

Research Focus

1. Dissecting oncogenic signaling networks in prostate cancer (e.g., kinase cascades, AR crosstalk)
2. Target discovery and validation using genome engineering and functional screens
3. Mechanistic studies linking genotype to therapeutic response and resistance
4. Preclinical evaluation of candidates in cellular and rodent cancer models
5. Development of quantitative, multi-omic assays to profile pathway activity and drug effects

Required Qualifications

• PhD (or equivalent) in a relevant field (e.g., Molecular Biology, Cell Biology, Genetics, Cancer Biology, Chemical Biology)
• Strong hands-on training in molecular biology, cell biology, mouse genetics, and signal transduction
• Experience with rodent models (e.g., xenograft, GEMM, orthotopic or PDX; stroke-related models)
• Bioinformatics and omics analysis (e.g., RNA-seq/single-cell RNA-seq).
• Demonstrated ability to work independently and drive projects to completion
• Excellent written communication skills

Preferred (not required)

• Experience in prostate cancer research, including models and mechanisms
• CRISPR perturbations, High-throughput screening
• Assay development for small-molecule or biologic agents

Appointment, Salary & Benefits

• Full-time appointment; initial one-year term with the possibility of annual renewal based on performance and mutual agreement
• Salary follows current NIH guidelines and is commensurate with experience and qualifications
• Access to University of Pittsburgh resources and collaborative research community

Application Instructions

Please email a single PDF containing:

1. Cover letter summarizing your research interests and career goals
2. Curriculum vitae
3. Contact information for 2–3 references

Tagged as: Life Sciences