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Postdoctoral Fellow
Postdoc Opening to Study Metabolic Signaling Full-time
The Xin Cai Lab at UT Southwestern Medical Center, Dallas, TX ([Please click the Apply button for the link or address] or https://labs.utsouthwestern.edu/cai-xin-lab) is recruiting postdoc candidates with an interest in signal transduction, cell and molecular biology, and biochemistry.
Our question: how do metabolites act as signaling molecules to allosterically regulate proteins?
Metabolites accumulate during diseases such as cancer, infection, and inflammation. Metabolites are classically viewed as energy sources, yet their high intracellular concentration enables direct binding and allosteric modulation of protein functions – a signaling function that remains largely unexplored. Using questions guided by human patient data, we conduct hypothesis-driven research through a combination of in vitro, cell-based, and ultimately in vivo models. We collaborate with biochemists and structural biologists to develop new methods to study protein-metabolite interactions.
Candidates must have passion for scientific discovery, strong work ethic, and interest in signal transduction, cell and molecular biology, and biochemistry. Please email xin.cai@utsouthwestern.edu:
- Detailed cover letter
- CV
- Names and contact for 3 references