• Set up, designed, and optimized mRNA-lipid nanoparticle (LNP) and downstream immune assays for neoantigen vaccine
• Developed cancer mouse models for vaccine, LNP, and adjuvant testing
• Explored novel mRNA vaccine design and structure
• Leading the vaccine development team
Contribution to Project (2)
• Analyzed tumor and blood sequencing data for early cancer detection test which resulted in 2 paper and commercial test
• Perform NGS lib prep and sequencing of patient samples
Contribution to Project (3)
• Developing platform for high-through put testing personal neoantigen using TIl, PBMCs and artificial APC
• Dissecting NGS and clinical data to develop targeting and combined therapy
• Working with other teams to establish neoantigen vaccine pipeline for personalized vaccine approaches
• Developing off-the-shelf vaccines