Subo Inpanathan

PhD

Postdoc

Bacteria host-pathogen functional assay ELISA (Cytokine Array) Flow Cytometry phagocytic assays

Peer-reviewed publication(s) 1st author peer-reviewed publication(s) Conference Poster(s) Conference Talks(s)

As the in vivo research lead, I oversaw the end-to-end lifecycle of our lab’s animal studies, from initial protocol design and ethical approval to hands-on execution. My work focused on the intersection of lysosomal biology and innate immunity, specifically how key transcription factors dictate macrophage function. To explore these mechanisms, I implemented a robust range of disease models, including peritonitis, ARDS, and chronic systemic infections.

I elucidated the complex interplay between macrophage lysosomal biogenesis and Salmonella pathogenesis. My research unveiled that Salmonella exerts precise spatio-temporal regulation over TFEB, a discovery that underscores how the pathogen’s growth phase dictates host transcriptional responses

I developed a novel fluorescent probe to enable visualization of bacterial killing in real-time in cellulo using traditional live-cell imaging applications, enabling higher throughput of bacterial survival assays.