Analytical Chemistry – Platform and Mass Spectrometry principal scientist Full-time

Platform Modalities Leader

GSK is seeking a Platform Modalities Leader to provide enterprise-level scientific leadership for the modernisation and evolution of Analytical Chemistry platforms supporting developing and complex therapeutic modalities.

This role owns the strategic expansion of analytical platform capability beyond the current small-molecule portfolio, enabling robust, scalable, and future-proof analysis of divalent small molecules, drug conjugates including Warhead Linker Payloads for Antibody Drug Conjugates (WLPs for ADCs), and oligonucleotides.

The position plays a critical role in ensuring analytical platforms are positioned to meet both near-term pipeline demands and longer-term modality evolution, while maintaining the highest standards of scientific excellence.

The successful candidate will be a recognised authority who leads from the laboratory, combining deep hands-on technical expertise with platform-level strategic thinking. Through modernisation of existing capabilities, introduction of new technologies, and integration of high-throughput purification and analytical workflows, this role will shape the future state of analytical platform delivery for emerging modalities.

This is a Scientific leader role G6 with 0 to 6 reports and will require extensive matrix leadership across chemistry, modality, informatics, automation, and technology organisations. Success will depend on the ability to influence direction, set standards, and deliver change across multiple reporting lines, with impact at programme, portfolio, and organisational level. The role will require full-time on-site presence.

Key Responsibilities

Platform Strategy, Ownership & Modernisation

• Provide end-to-end scientific ownership of existing analytical and purification platforms at Stevenage and supporting small molecule and next-generation modalities, including divalent small molecules, WLPs, and oligonucleotides.
• Define and drive platform strategy and modernisation, ensuring analytical capabilities are scalable, automation-ready, and aligned to future modality and pipeline needs.
• Critically evaluate existing platforms and workflows, setting direction for capability enhancement, technology adoption, and retirement where appropriate.
• Act as a key technical voice shaping capability roadmaps and investment priorities for analytical platforms.

Senior Scientific & Technical Leadership

• Lead from the laboratory on the most complex and high-impact analytical challenges, providing authoritative input into method development, troubleshooting, and platform design.
• Serve as a recognised internal expert in platform analytics, guiding experimental strategy, data interpretation, and risk-based decision-making.
• Set expectations for robustness, reproducibility, and data quality, influencing best practice across analytical workflows and teams.

High-Throughput & Workflow Integration

• Drive the strategic integration of high-throughput purification and analytical workflows to enable efficient, end-to-end support of emerging modality pipelines.
• Provide scientific leadership at the interface of analysis, bespoke purification, informatics, and automation to ensure platform coherence and long-term sustainability.
• Influence platform design choices to maximise throughput, data quality, and downstream usability.

Enterprise Collaboration & Influence

• Operate as a senior matrix leader, partnering with Discovery Chemistry, Modality teams, Informatics, Automation, and external collaborators to align platform capabilities with business priorities.
• Communicate analytical platform strategy, capability, limitations, and opportunity clearly to senior scientific and functional stakeholders.
• Translate complex technical capability into clear value propositions and guidance for project and portfolio-level decision-making.

Governance, Quality & Continuous Improvement

• Ensure analytical platforms meet high standards of quality, safety, and compliance, consistent with organisational and regulatory expectations.
• Contribute to governance forums, providing expert input into prioritisation, risk assessment, and investment decisions related to analytical platforms.
• Drive continuous improvement using data-led insight, performance metrics, and lessons learned across programmes and modalities.

Basic Qualifications & Skills

• BSc or equivalent in Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related discipline, with at least 10 years of postgraduate experience in analytical chemistry.
• Deep, demonstrable expertise in analytical platforms and associated analytical techniques relevant to modern drug modalities (e.g. LC-MS, HRMS, advanced separations, high-throughput and automated analysis).
• Proven experience modernising or transforming analytical platforms to support new modalities, including at least one of bifunctional molecules, oligonucleotides, or WLPs for ADCs.
• Strong scientific judgement with the credibility to lead complex decisions from the laboratory through to platform strategy.
• Experience influencing and shaping high-throughput and automated analytical or purification solutions.
• Extensive experience of matrix leadership, delivering outcomes through influence across multiple functions and reporting lines.
• Strong team player with excellent communication skills and the ability to engage, challenge, and influence senior scientific and functional leaders as evidenced by publication and/or external presentations.

Preferred Qualifications & Skills

• PhD in Analytical Chemistry, Chemistry, or a related discipline, or MSc with significant and directly relevant experience.
• Hands-on experience supporting complex or emerging modalities such as divalent molecules, WLPs, and oligonucleotides.
• Experience shaping enterprise-level platform strategy, long-term capability roadmaps, and/or capital investment proposals.
• Track record of delivering step-change improvements through cross-functional partnership spanning science, informatics, and technology.

This role will be based 100% on site.

How to apply If this role speaks to you, please apply now. In your application, use the cover letter or CV to describe how your experience meets the requirements. We encourage candidates from all backgrounds to apply.

Application close date – 11th June 2026