Associate Principal Scientist, TCE Discovery & Biology Full-time

Associate Principal Scientist

We are seeking an experienced and highly motivated Associate Principal Scientist to join our Immuno-Oncology discovery team and contribute to the discovery and development of next-generation T-cell engager (TCE) therapeutics. This role is designed for a scientifically mature, hands-on investigator who can lead defined biology workstreams while continuing to design, execute, and troubleshoot critical experiments at the bench.

The successful candidate will bridge laboratory execution and project-level scientific leadership. They will translate program questions into integrated experimental plans, generate and interpret decision-quality data, provide technical direction to colleagues and external partners, and influence molecule optimization and progression decisions from early discovery through lead optimization and translational assessment.

The anticipated balance is approximately 40–60% laboratory work, adjusted by project phase and team needs. The role is not expected to carry the full portfolio, budget, or people-management accountability of a Principal Scientist / Associate Director, but it should operate with substantial independence and visible matrix leadership.

Key Responsibilities

• Hands-On TCE Functional Biology
• Assay Strategy and Technical Leadership
• Molecule Characterization and Program Contribution
• Translational and Mechanistic Studies
• Matrix, External, and Team Leadership

Essential Qualifications and Experience

• PhD in Immunology, Cancer Biology, Cell Biology, Pharmacology, Molecular Biology, or a related discipline, with relevant postdoctoral and/or industry experience.
• Strong hands-on expertise in T-cell biology, tumor immunology, immune-mediated cytotoxicity, and mammalian cell-based functional assays.
• Demonstrated experience with TCEs, bispecific or multispecific antibodies, or other immune-cell-redirecting therapeutics.
• Advanced practical expertise in primary human immune-cell culture and multiparameter flow cytometry.
• Proven ability to independently design, execute, troubleshoot, and interpret complex experiments and to convert findings into actionable project recommendations.
• Experience developing quantitative assay cascades and differentiating molecules based on mechanism, potency, selectivity, cytokine profile, and translational relevance.
• Ability to lead a defined scientific workstream, influence matrix teams, and deliver against project milestones with limited supervision.
• Fluency in spoken and written English, with the ability to participate confidently in scientific discussions, prepare clear documentation, and deliver effective presentations.
• Excellent communication and interpersonal skills, with demonstrated ability to communicate complex scientific concepts, align stakeholders, influence decisions, and collaborate effectively in a complex, cross-functional, and multicultural environment.

Preferred Qualifications

• Experience supporting TCE programs through lead optimization, candidate nomination, or IND-enabling preparation.
• Expertise in antigen-density biology, affinity and avidity tuning, epitope selection, molecular-format comparison, receptor occupancy, or cytokine-management strategies.
• Experience with serial-killing assays, complex co-culture systems, patient-derived samples, organoids, ex vivo tumor models, or high-dimensional immune profiling.
• Experience commissioning and scientifically overseeing CRO studies or external collaborations.
• Familiarity with in vivo pharmacology and the integration of in vitro potency, PK, pharmacodynamics, efficacy, and safety findings.
• A record of scientific contribution through publications, patents, conference presentations, or advancement of industry discovery programs.