Clinical Research Fellow Full-time

Clinical Research Fellow

We are seeking a Clinical Research Fellow to join our Motor Neuron Disease (MND) research group to lead a highly translational biomarker project funded by a Biogen Sponsored Research Agreement. The group has developed a quantitative whole-body muscle MRI protocol designed to act as a highly responsive outcome measure in Amyotrophic Lateral Sclerosis (ALS). Technology advances using artificial intelligence in sequence acquisition and analysis now mean we can develop our protocol to be more accurate, reliable, sensitive, and faster.

This study will aim to optimise our MRI outcome measures using these technological advances, mapping disease progression, and correlating structural muscle changes with clinical phenotypes. You will play a pivotal role in monitoring patients receiving novel gene-targeted therapies, including the Tofersen cohort expansion.

The post is suitable for a neurology trainee who wishes to develop expertise in motor neuron disease, biomarkers, and clinical trials. There may also be the opportunity to enrol for a PhD focused on MRI and translational neuroscience.

While this role is anchored in ALS research, you will be embedded within the wider Centre for Neuromuscular Diseases. You will gain comprehensive exposure to a broad spectrum of neuromuscular pathology, managing a diverse cohort of patients for your MRI studies, including those with Spinal and Bulbar Muscular Atrophy (SBMA), Inclusion Body Myositis (IBM), Frontotemporal Dementia (FTD), Distal Hereditary Motor Neuropathy (dHMN), Charcot-Marie-Tooth disease (CMT), Spinal Muscular Atrophy (SMA), and asymptomatic genetic mutation carriers.

An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required.

The post is available from September 2026 and is funded by Biogen for three years in the first instance.

If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team.

Informal enquiries regarding the role can be addressed to Dr Oliver Ziff.

For a full job description please visit UCL's online recruitment portal and search using vacancy reference B02-10825. To apply, please upload a current CV, complete the online application form, and use the supporting statement section or upload a cover letter to outline how you meet the essential and desirable criteria for the role. Please do not upload any additional attachments as these will not be considered by the selection panel.

The role is offered in the range of £51,140 – £78,670 per annum including London Allowance, on the CL, RDPS, or StR scale, dependent on NHS contract and/or stage of clinical training.

As well as the exciting opportunities this role presents, we also offer great benefits. We will consider applications to work on a part-time, flexible, and job share basis wherever possible.

This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff.

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.