The laboratory of new Assistant Professor Vignesh Kasinath in the Department of Biochemistry at CU Boulder located in Boulder, Colorado (https://vigneshkasinath.org) is seeking applications for talented and motivated postdoctoral scholars interested in using cryo-electron microscopy (cryo-EM), and/or cryo-electron tomography (cryo-ET) to decipher the structural and mechanistic role of large macromolecular assemblies in gene regulation.
Dr. Vignesh Kasinath was a Helen Hay Whitney Postdoctoral Fellow with Prof. Eva Nogales at University of California, Berkeley, and a NIH K99/R00 Pathway to Independence Award recipient with Prof. Eva Nogales & Prof. Elizabeth Villa (at University of California, San Diego). Vignesh’s work with Prof. Eva Nogales has revealed structural and mechanistic insights into the regulation of chromatin modifier PRC2 (Polycomb Repressive Complex 2) using single-particle cryo-electron microscopy (cryo-EM). Vignesh’s more recent work revolves around the characterization of large macromolecular assemblies regulating chromosome architecture using cryo-focussed ion beam milling (cryo-FIB) and cryo-electron tomography (cryo-ET).
CU Boulder, besides being a phenomenal place to live, has a state-of-the art Titan Krios G3i with a Gatan K3 Direct Electron Detector Camera, FEI Tecnai F30 with a Gatan K2 Summit Direct Electron Detector Camera, FEI Tecnai F20 with a Gatan K3 Direct Electron Detector Camera, and a FEI Tecnai T12 Spirit with a 4k x 4k CCD camera. CU Boulder is also currently being set up as a NIH-centre for cryo-ET with the expected arrival of FEI Aquilos 2 cryo-FIB, Leica THUNDER CLEM, and Cryosol Vitrojet.
The lab offers the opportunity to work directly with the PI on many research projects involving either single-particle cryo-EM or cryo-FIB/cryo-ET. Candidates with a strong interest in structural biology, cryo-EM, a track record of publications in biochemistry or biophysics and above all, the desire and ability to learn are encouraged to apply. Candidate with expertise in one or more areas of biochemistry, molecular biology, or structural biology (NMR, X-ray crystallography, cryo-EM) are highly desired. Experience with insect cell expression and mammalian cell culture would be highly advantageous but not necessary. The candidate will play a key role in shaping the research environment in the lab. There is hence an immense opportunity to develop professionally both in research collaborations and in mentoring.
Applicants with Ph D or equivalent degree in either biochemistry, biophysics, structural biology, cell biology or related field must apply using the following URL:
Tagged as: Chemistry, Life Sciences, Physics
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